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AKT2 — NEUROD1
Text-mined interactions from Literome
Bang et al., J Cell Sci 2001
:
Overexpression of
Akt inhibits NGF induced growth arrest and
neuronal differentiation of PC12 cells ... To investigate the
role of
Akt in nerve growth factor (NGF) induced
neuronal differentiation , PC12 cells ectopically expressing wild-type or dominant-inhibitory forms of Akt were analyzed
Taraviras et al., Eur J Cell Biol 2002
(MAP Kinase Signaling System) :
Epinephrine
induced neuronal differentiation of PC12alpha2 cells through alpha2-AR activation in a subtype dependent manner, internalization of all human alpha2-AR subtypes, and activation of mitogen activated protein kinase ( MAPK ) and the serine-threonine protein kinase
Akt
Oishi et al., Proc Natl Acad Sci U S A 2009
:
Furthermore, active
Akt increased the protein levels and transactivation activity of Mash1, a proneural basic helix-loop-helix protein required for the generation of neocortical GABAergic neurons, and Mash1 was
required for Akt induced
neuronal differentiation
Park et al., BMB Rep 2012
:
However, the exact
role of
Akt in
neuronal differentiation is still controversial
Noh et al., Mol Biol (Mosk) 2012
:
Furthermore, NAC enhanced
neuronal differentiation was
mediated by activation of
Akt
Zhang et al., Neural development 2013
:
AKT activation by N-cadherin
regulates beta-catenin signaling and
neuronal differentiation during cortical development ... These results show that N-cadherin regulates ß-catenin signaling through both Wnt and AKT, and suggest a previously unrecognized
role for
AKT in
neuronal differentiation and cell survival during cortical development