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NEUROD2 — NEUROG2
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Andersson et al., Exp Cell Res 2007
:
We show that over-expression of
Ngn2 in these progenitors
results in increased
neuronal differentiation but does not promote mesDA formation
Gasa et al., Differentiation 2008
:
Interestingly, in addition to NeuroD1,
Neurog3 also
induced both
NeuroD2 and NeuroD4 gene expression
Hindley et al., Development 2012
:
Neurogenin 2 (Ngn2) controls
neuronal differentiation cell-autonomously by transcriptional activation of targets such as NeuroD, while simultaneously controlling progenitor maintenance non-cell-autonomously by upregulating Delta expression and Notch signalling
Lacomme et al., Mol Cell Biol 2012
:
Proneural
NEUROG2 ( neurogenin 2 [ Ngn2 ] ) is
essential for neuronal commitment, cell cycle withdrawal, and
neuronal differentiation
Pan et al., J Biol Chem 2012
:
Furthermore, shERK5 attenuates both transcription and
neuronal differentiation mediated by
Neurogenin 2 , a transcription factor expressed in adult hippocampal neural progenitor cells
Thoma et al., PloS one 2012
:
Ngn2 induced
neuronal differentiation did not require any additional external or internal factors and occurred even under pluripotency promoting conditions
Guichet et al., Glia 2013
(Brain Neoplasms...) :
In the U87 glioma line,
Ngn2 could not
induce neuronal differentiation although proliferation in vitro and tumoral growth in vivo were strongly reduced