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JUN — NFKBIA
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Takata et al., Br J Pharmacol 2001
:
5. Pravastatin inhibit the
activator protein-1 activity, but did not
inhibit the activation of
IkappaB-alpha
Zingarelli et al., FASEB J 2002
(Myocardial Infarction...) :
These events were preceded by degradation of inhibitor kappaBalpha ( IkappaBalpha ),
activation of
IkappaB kinase complex (IKK) and c-Jun-NH2-terminal kinase (JNK), and subsequently activation of nuclear factor-kappaB (NF-kappaB) and
activator protein 1 (AP-1) as early as 15 min after reperfusion ... These events were preceded by degradation of inhibitor kappaBalpha (
IkappaBalpha ),
activation of IkappaB kinase complex (IKK) and
c-Jun-NH2-terminal kinase (JNK) , and subsequently activation of nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) as early as 15 min after reperfusion
Zingarelli et al., J Immunol 2003
(Bacteremia...) :
These events were preceded by degradation of inhibitor kappaBalpha ( IkappaBalpha ),
activation of
IkappaB kinase complex , and
c-Jun NH ( 2 ) -terminal kinase and, subsequently, activation of NF-kappaB and AP-1 in the lung
Krappmann et al., Mol Cell Biol 2004
:
The
IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide induced gene expression and
control subordinate activation of
AP-1
Aneja et al., Mol Med 2004
(Myocardial Reperfusion Injury) :
These events were associated with cytosol degradation of inhibitor kappaB-alpha, activation of
IkappaB kinase , phosphorylation of c-Jun, and subsequent
activation of nuclear factor-kappaB and
activator protein-1 in the infarcted heart
Greenberg et al., Alcohol 1998
:
ETOH does not directly inhibit NFkappaB or
AP-1 , in vivo, but rather
inhibits LPS induced activation of the MEKK/MAP kinase system and inhibition of inhibitory protein
IkappaBalpha required for formation of AP-1 and NFkappaB, respectively