Zhao et al., Int J Radiat Biol 1999
(Leukemia, Lymphoid) :
[Ca2+ ] i-chelating BAPTA-AM ( 5 microM ) and/or DNase gamma inhibiting Zn2+ ( 0.5 mM ) inhibited approximately 50 % of induced apoptosis and DNA laddering, indicating a 50 % participation of Ca2+/Mg2+ dependent DNase gamma Shiokawa et al., Biochem J 1997
:
In accordance with previous studies, homogeneously purified DNase gamma requires both Ca2+ and Mg2+ for activity