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PPARA — STAT5B

Pathways - manually collected, often from reviews:

• BioCarta mechanism of gene regulation by peroxisome proliferators via ppara: PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1) → 0005667 (JUN/RELA/SP1/STAT5A/STAT5B) (modification, collaborate)
  
• BioCarta mechanism of gene regulation by peroxisome proliferators via ppara: 0005667 (JUN/RELA/SP1/STAT5A/STAT5B) → PPAR-alpha (PPARA) (modification, collaborate)

Text-mined interactions from Literome

Zhou et al., J Biol Chem 1999 : STAT5b inhibition was not reversed by overexpression of the heterodimerization partner of PPAR ( retinoid X receptor ) or the nuclear receptor coactivators P300 and SRC-1, suggesting that STAT5b does not inhibit PPARalpha by competing for these limiting cellular cofactors
Shipley et al., Mol Pharmacol 2003 : PPAR did not block STAT5b tyrosine phosphorylation or inhibit DNA binding activity ... Transcriptionally inactive, dominant negative PPAR mutants did not block STAT5b inhibition by wild-type PPAR, indicating that PPAR target gene transcription is not required
Zhou et al., J Biol Chem 1999 : GH inhibition of PPARalpha activity required GH receptor and STAT5b and was not observed using GH-activated STAT1 in place of STAT5b