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Rimoldi et al., Biochem Biophys Res Commun 2001 (Diabetes Mellitus, Experimental) : Effects of diabetes and insulin on hepatic delta6 desaturase gene expression ... In the present study, we used streptozotocin induced diabetic rats in order to determine the regulatory role of insulin on the expression of hepatic Delta6 desaturase gene ... Therefore, our data demonstrate that the activity of hepatic Delta6 desaturase in response to insulin is, at least in part, regulated by pretranslational events that require the synthesis of an unknown protein ( s )
Nakamura et al., Biochem Soc Trans 2002 : A key regulator of desaturase gene expression is sterol-regulatory element binding protein-1c ( SREBP-1c ), which mediates transcriptional activation of the SCD and D6D genes by insulin and inhibition by HUFAs
Brenner et al., Prostaglandins Leukot Essent Fatty Acids 2003 (Diabetes Mellitus, Experimental) : In experimental diabetes mellitus type-1, the depressed delta6 desaturase is restored by insulin stimulation of the gene expression of its mRNA