◀ Back to INS

FOXA2 — INS

Pathways - manually collected, often from reviews:

• NCI Pathway Database FOXA2 and FOXA3 transcription factor networks: FOXA2 (FOXA2) → Insulin (INS) (transcription, activates) Zhang et al., Cell Metab 2005*, Unterman et al., Biochem Biophys Res Commun 1994*
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database FOXA2 and FOXA3 transcription factor networks: FOXA2 (FOXA2) → Insulin (INS) (transcription, activates) Scassa et al., J Biol Chem 2004*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database FOXA1 transcription factor network: FOXA2 (FOXA2) → Insulin (INS) (transcription, activates) Duncan et al., Science 1998*
  Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Shen et al., J Biol Chem 2001 (Hypoglycemia) : Foxa1 has been shown to be required for glucagon secretion in the pancreas, whereas Foxa2 is critical for the regulation of insulin secretion in pancreatic beta-cells
Shih et al., Proc Natl Acad Sci U S A 2002 : In mice, a heterozygous mutation in Pdx-1 alone, but not Hnf-1alpha ( +/- ), Hnf-3beta ( +/- ), or Hnf-4alpha ( +/- ), causes impaired glucose stimulated insulin secretion in mice
Wolfrum et al., Proc Natl Acad Sci U S A 2003 : Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt mediated phosphorylation and nuclear/cytosolic localization ... Here, we show that the activation of phosphatidylinositol 3-kinase-Akt by insulin induces Foxa-2 phosphorylation, nuclear exclusion, and inhibition of Foxa-2 dependent transcriptional activity
Lantz et al., J Clin Invest 2004 : Using isolated islets, we found that Foxa2 deficiency resulted in excessive insulin release in response to amino acids and complete loss of glucose stimulated insulin secretion
Wolfrum et al., Nature 2004 (Diabetes Mellitus...) : Here we show that in normal mice, plasma insulin inhibits the forkhead transcription factor Foxa2 by nuclear exclusion and that in the fasted ( low insulin ) state Foxa2 activates transcriptional programmes of lipid metabolism and ketogenesis
Gao et al., Cell Metab 2007 (Calcium Signaling...) : Foxa2 controls vesicle docking and insulin secretion in mature Beta cells
Iacobazzi et al., Biochem Biophys Res Commun 2009 : Role of FOXA in mitochondrial citrate carrier gene expression and insulin secretion ... These results show that FOXA plays a role in the transcriptional regulation of CIC and in insulin secretion
Howell et al., J Biol Chem 2009 : Foxa2 is activated under fasting conditions but is inhibited by insulin signaling via phosphatidylinositol 3-kinase/AKT in a phosphorylation dependent manner, which results in its nuclear exclusion
Moya et al., PloS one 2012 (Fatty Liver) : In the mouse liver, Foxa2 is repressed by insulin and mediates fasting responses