Zhang et al., J Cell Biochem 2009
:
This insulin signal results in Tyr phosphorylation and catalytic activation of phosphatase PHLPP1 via a PI 3-kinase independent, wortmannin-insensitive signaling pathway
Kanan et al., J Neurochem 2010
:
We made a novel finding in this study that both PHLPP and PHLPPL activities were significantly decreased in the presence of insulin ex vivo
Andreozzi et al., Diabetologia 2011
(Insulin Resistance...) :
To study the effect of PHLPP on insulin signalling, PHLPP ( also known as PHLPP1 ) was overexpressed in HepG2 and L6 cells ... Overexpression of PHLPP1 in HepG2 cells and L6 myoblasts resulted in impaired insulin signalling involving Akt/glycogen synthase kinase 3, glycogen synthesis and glucose transport