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GRB2 — IL4
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of GRB2-IRS2
→
IL4
(increases)
Zamorano et al., Cell Res 2001*
Evidence: association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL4 treatment although both proteins were expressed IL4 induced association of IRS2 with GRB2 in B cell blasts
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BioCarta il 4 signaling pathway:
IRS1/2/GRB2 complex (GRB2)
→
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
(modification, collaborate)
-
BioCarta il 4 signaling pathway:
IRS1/2/GRB2 complex (GRB2)
→
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
(modification, collaborate)
-
BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4)
→
GRB2
(modification, collaborate)
-
BioCarta il 4 signaling pathway:
IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R)
→
GRB2
(modification, collaborate)
-
NCI Pathway Database IL4-mediated signaling events:
GRB2 (GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
GRB2 (GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
-
NCI Pathway Database IL4-mediated signaling events:
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2)
→
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D)
(modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
Text-mined interactions from Literome
Zamorano et al., Cell Res 2001
:
However,
IL-4 induced association of IRS2 with
GRB2 in B cell blasts
Lee et al., Phytother Res 2013
(Inflammation) :
GRb1 significantly
reduced the upregulation of tumor necrosis factor-a,
interleukin (IL)-1ß and IL-6 mRNA in the brain tissue at 4?h after LPS injection
Welham et al., J Biol Chem 1994
:
Interleukin (IL)-3 and granulocyte/macrophage colony stimulating factor, but not
IL-4 ,
induce tyrosine phosphorylation, activation, and association of SHPTP2 with
Grb2 and phosphatidylinositol 3'-kinase