Gene interactions and pathways from curated databases and text-mining

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GRB2 — IL4

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of GRB2-IRS2 → IL4 (increases) Zamorano et al., Cell Res 2001*
    Evidence: association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL4 treatment although both proteins were expressed IL4 induced association of IRS2 with GRB2 in B cell blasts
  • BioCarta il 4 signaling pathway: IRS1/2/GRB2 complex (GRB2) → IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) (modification, collaborate)
  • BioCarta il 4 signaling pathway: IRS1/2/GRB2 complex (GRB2) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
  • BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) → GRB2 (modification, collaborate)
  • BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) → GRB2 (modification, collaborate)
  • NCI Pathway Database IL4-mediated signaling events: GRB2 (GRB2) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2) (modification, collaborate)
    Wery et al., J Biol Chem 1996
    Evidence: physical interaction
  • NCI Pathway Database IL4-mediated signaling events: GRB2 (GRB2) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) (modification, collaborate)
    Wery et al., J Biol Chem 1996
    Evidence: physical interaction
  • NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) (modification, collaborate)
    Wery et al., J Biol Chem 1996
    Evidence: physical interaction

Text-mined interactions from Literome

Zamorano et al., Cell Res 2001 : However, IL-4 induced association of IRS2 with GRB2 in B cell blasts
Lee et al., Phytother Res 2013 (Inflammation) : GRb1 significantly reduced the upregulation of tumor necrosis factor-a, interleukin (IL)-1ß and IL-6 mRNA in the brain tissue at 4?h after LPS injection
Welham et al., J Biol Chem 1994 : Interleukin (IL)-3 and granulocyte/macrophage colony stimulating factor, but not IL-4 , induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase