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Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Hirota et al., J Biol Chem 1999
:
In the nucleus, however,
TRX enhances
NF-kappaB transcriptional activities by enhancing its ability to bind DNA ... This two-step
TRX dependent regulation of the
NF-kappaB complex may be a novel activation mechanism of redox-sensitive transcription factors
Zhang et al., Am J Physiol 1999
:
Nitric oxide induced reduction of lung cell and whole lung
thioredoxin expression is
regulated by
NF-kappaB
Chang et al., Am J Respir Cell Mol Biol 2000
:
Taking these data together, a novel mechanism is proposed in which ATRA activates promoter activity of IL-8 gene through
TRX dependent
NF-kappaB activation
Hirota et al., Biochem Biophys Res Commun 2000
:
Nucleoredoxin, glutaredoxin, and
thioredoxin differentially
regulate NF-kappaB , AP-1, and CREB activation in HEK293 cells
Das et al., J Biol Chem 2001
:
c-Jun NH2-terminal kinase mediated redox dependent degradation of IkappaB :
role of
thioredoxin in
NF-kappaB activation ... In addition, only the reduced form of
thioredoxin activated
NF-kappaB , whereas the oxidized form was without any effect ... Overexpression of human
thioredoxin also
caused activation of
NF-kappaB and degradation of IkappaB ... On the contrary, dominant negative redox-inactive mutant
thioredoxin expression did not
activate NF-kappaB , further confirming the redox dependent activation of NF-kappaB ... We also investigated the mechanism of
activation of
NF-kappaB by
thioredoxin
Gebel et al., Toxicological sciences : an official journal of the Society of Toxicology 2001
:
The activity of
NF-kappaB in Swiss 3T3 cells exposed to aqueous extracts of cigarette smoke is
dependent on
thioredoxin
Takeuchi et al., Antioxid Redox Signal 2000
:
Thioredoxin inhibits tumor necrosis factor- or interleukin-1 induced
NF-kappaB activation at a level upstream of NF-kappaB inducing kinase ... To elucidate the roles of TRX in the signal transduction of the cytokines, we investigated the
effects of
TRX on
NF-kappaB activation induced by cytokine treatment or by overexpression of the signaling molecules ... In addition, we show that
TRX inhibits
NF-kappaB activation in a manner different from that for SAPK ( stress activated protein kinase ) inhibition
Gan et al., Zhonghua Yi Xue Za Zhi 2002
(Colitis, Ulcerative) :
Glucocorticoids and
SASP strongly
inhibited NF-kappaB activation and expression
Gan et al., Zhonghua Nei Ke Za Zhi 2002
(Colitis, Ulcerative) :
( 2 ) Glucocorticoids and
SASP strongly
inhibited NF-kappaB activation and signficantly decreased the expression of IL-1beta mRNA and IL-8 mRNA
Kontou et al., Biol Chem 2003
(Chromosomal Instability...) :
Cotransfection of the NF-kappaB dependent CAT plasmid with the Trx/nuc-plasmid into FA fibroblasts increased the CAT expression to almost that of control cells, indicating that in this model system with diminished thioredoxin content
NF-kappaB requires
thioredoxin for binding to its specific promotor
Matthews et al., Nucleic Acids Res 1992
:
Thioredoxin regulates the DNA binding activity of
NF-kappa B by reduction of a disulphide bond involving cysteine 62
Chen et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2004
(Colitis, Ulcerative) :
Glucocorticoids and
SASP markedly
inhibited NF-kappaB activation and significantly decreased mRNA and protein expression of ICAM-1 and VCAM-1 ( P < 0.05 )
Chandrasekaran et al., J Mol Graph Model 2008
:
Oxidative stimuli in the cytosol are associated with nuclear translocation of NF-kappa B, whereas in the nucleus, reductive activation by
thioredoxin is
required for
NF-kappa B to bind to DNA and activate target genes
Schenk et al., Proc Natl Acad Sci U S A 1994
:
These results suggest that
thioredoxin plays an important role in the regulation of transcriptional processes and oppositely
affects NF-kappa B and AP-1 activation
Hayashi et al., J Biol Chem 1993
:
We show that a cellular reducing catalyst
thioredoxin (Trx) plays a major role in activation of the DNA binding of
NF kappa B in vitro and stimulation of transcription from the NF kappa B-dependent gene expression ... We demonstrate evidence suggesting that redox
regulation of
NF kappa B by
Trx might be exerted at a step after dissociation of the inhibitory molecule I kappa B, a cytosolic anchoring protein for NF kappa B