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MAPK3 — PLAT
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Son et al., Biochem Biophys Res Commun 2002
(MAP Kinase Signaling System) :
Soluble NCAM transiently inhibited
tPA mRNA expression levels in a
MAPK dependent manner, while stimulation of MAPK alone induced tPA reduction in cells ... In turn,
MAPK activation may
cause tPA degradation or a decrease in expression to promote synaptic plasticity
Yang et al., Endocrine 2008
:
We have analyzed a possible
role of
mitogen activated protein kinase ( MAPK ) and activator protein-1 (AP-1) in the regulation of FSH induced tissue
type plasminogen activator (tPA) production in granulosa cells (GCs) prepared from DES treated immature rats ; Treatment of the cells in the presence of FSH with MAPK inhibitors, such as UO126 or SB203580, significantly decreased the FSH induced tPA production, suggesting that multiple signaling pathways may be involved in FSH regulated tPA expression
Roda et al., Gastroenterology 2009
(Adenocarcinoma...) :
Down-regulation of Gal-1 abolished the
effects of
tPA on
extracellular signal regulated kinase 1/2 activation, cell proliferation, and invasion, both in pancreatic and in tumor derived fibroblasts ... Down-regulation of Gal-1 by small interference RNA was used to analyze the
involvement of
Gal-1/tPA interaction in
extracellular signal regulated kinase 1/2 activation, cell proliferation, and invasion in pancreatic and fibroblastic cells
Armstead et al., Pediatr Crit Care Med 2011
(Toxoplasmosis, Cerebral) :
Red blood
cells-tissue plasminogen activator blocked c-Jun-N-terminal kinase but
potentiated p38
mitogen activated protein kinase upregulation after photothrombotic injury