Kuznetsov et al., Oncogene 2005
(Neoplasms, Experimental...) :
The dioxin/aryl hydrocarbon receptor mediates downregulation of osteopontin gene expression in a mouse model of gastric tumourigenesis
Simoes et al., Am J Respir Crit Care Med 2009
(Asthma...) :
Based on its ability to induce smooth muscle and fibroblast proliferation and migration we hypothesize that OPN regulates lung remodeling and also affects subsequent airway hyperresponsiveness (AHR) Chuang et al., Gene 2012
(Lung Neoplasms) :
Up-regulation of osteopontin expression by aryl hydrocarbon receptor via both ligand dependent and ligand independent pathways in lung cancer ... In this study we demonstrated that AhR positively regulates OPN expression in lung cancer ... This study suggested that both overexpression of un-induced AhR ( in cases of non-smokers with high level of AhR ) and ligand activated AhR ( such as smokers ) contribute to up-regulation of OPN that in turn leads to lung tumorigenesis