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NR4A2 — SPP1

Text-mined interactions from Literome

Lammi et al., Mol Endocrinol 2004 : Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts ... Transfection of Nurr1 in osteoblastic cells increased OPN mRNA expression ... A dominant negative Nurr1 variant abolished the ability of PTH to induce OPN expression, suggesting that Nurr1 is involved in mediating the regulation of OPN by PTH ... The activation of the OPN promoter was mediated by the monomeric form of Nurr1, required direct binding of Nurr1 to the OPN promoter, and was dependent on the amino-terminal transactivation function-1 ... We show that Nurr1 and vitamin D activate the OPN promoter in a synergistic fashion, whereas Nurr1 mediated transactivation of the OPN promoter is repressed by estrogen related receptors ... In conclusion, Nurr1 activates the OPN promoter directly in osteoblastic cells, suggesting a role for Nurr1 in the regulation of bone homeostasis
Zagani et al., Gastroenterology 2009 (Adenomatous Polyposis Coli...) : NR4A2 activated the osteopontin promoter in CT26 cells ; this effect was blocked by mutation of the NR4A2 binding response element, cotransfection of a dominant negative form of NR4A2, and small inhibitory RNA against NR4A2