◀ Back to TP53

TP53 — UBE4B

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: UBE4B — TP53 (physical association, affinity chromatography technology) Wu et al., Nat Med 2011*
• IRef Biogrid Interaction: UBE4B — TP53 (direct interaction, enzymatic study) Wu et al., Nat Med 2011*
• IRef Biogrid Interaction: UBE4B — TP53 (colocalization, biochemical) Wu et al., Nat Med 2011*
• IRef Biogrid Interaction: UBE4B — TP53 (direct interaction, pull down) Wu et al., Nat Med 2011*

Text-mined interactions from Literome

Wu et al., Nat Med 2011 (Brain Neoplasms) : UBE4B promotes Hdm2 mediated degradation of the tumor suppressor p53 ... Notably, silencing UBE4B expression impairs xenotransplanted tumor growth in a p53 dependent manner and overexpression of UBE4B correlates with decreased expression of p53 in these tumors
Wu et al., Cell cycle (Georgetown, Tex.) 2011 : Our findings revealed that UBE4B negatively regulates the level of p53 and inhibits p53 dependent transactivation and apoptosis