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TNF — ZFP36
Text-mined interactions from Literome
Inglot et al., Arch Immunol Ther Exp (Warsz) 1999
:
TTP* stimulated synthesis of IFN and
TNF in the whole blood cultures
Johnson et al., Oncogene 2000
:
The immediate early protein
tristetraprolin (TTP) is
required to prevent inappropriate production of the cytokine
TNF-alpha , and is a member of a zinc finger protein family that is associated with RNA binding ...
TTP expression is
induced by
TNF-alpha , and evidence indicates that TTP can bind and destabilize the TNF-alpha mRNA
Fairhurst et al., Arthritis Res Ther 2003
:
These data establish the cytoplasmic location of TTP, supporting a major role for this protein in regulating TNF production, and suggest that
TTP levels are not
regulated solely by
TNF
Suzuki et al., J Exp Med 2003
:
Furthermore, IL-4 induced the expression of tristetraprolin (TTP), an RNA binding protein that promotes decay of ARE containing mRNA, in mast cells by a Stat6 dependent mechanism, and the depletion of
TTP expression by RNA interference
prevented IL-4 induced down-regulation of
TNF-alpha production in mast cells
Tsutsumi et al., J Rheumatol 2004
(Arthritis, Rheumatoid) :
A low TTP/TNF-a gene expression ratio could indicate failure of RA patients to produce adequate amounts of
TTP in
response to increased
TNF-a production
Fukae et al., Arthritis Rheum 2005
(Arthritis, Rheumatoid) :
The
effects of
TIS11B on
TNFalpha expression were examined using an overexpression model of TIS11B in RAW264.7 cells
Carrick et al., J Autoimmun 2006
(Arthritis, Rheumatoid...) :
The ZFP36 gene codes for
TTP , a
regulator of
TNF alpha
Smoak et al., Mol Cell Biol 2006
:
Small interfering RNAs to TTP significantly prevent this effect, and a cell line stably expressing a short-hairpin RNA to TTP conclusively establishes that
TTP is
critical for dexamethasone inhibition of
TNF-alpha mRNA expression
Deleault et al., Mol Immunol 2008
(MAP Kinase Signaling System) :
Tristetraprolin regulates
TNF TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways
Sze et al., Biochem J 2008
:
Activation of the JNK signalling pathway by
TNFalpha up-regulated the expression of an RNA binding protein,
TTP ( tristetraprolin )
Jalonen et al., J Pharmacol Exp Ther 2008
:
By binding to ARE,
TTP increases the degradation of TNF-alpha mRNA, thereby reducing the expression of
TNF-alpha
Semaan et al., PloS one 2011
(Arthritis, Rheumatoid) :
Conversely, transfection of miR-346 in LPS activated THP-1 cells increased
TTP mRNA expression and
inhibited TNF-a release
Qi et al., Mol Cell Biol 2012
:
Furthermore, knockdown of
TTP increases the rate of biosynthesis of
TNF-a , suggesting that TTP can exert effects at translational levels
Qin et al., Nutrition 2012
(MAP Kinase Signaling System) :
Ex vivo, the CE significantly decreased the amount of apolipoprotein-B48 secretion into the media,
inhibited the mRNA expression of genes of the inflammatory cytokines, interleukin-1ß, interleukin-6, and
tumor necrosis factor-a , and induced the expression of the anti-inflammatory gene,
Zfp36
Chen et al., Biochem Biophys Res Commun 2012
(Inflammation) :
Excessive
TNF-a expression
induces tristetraprolin (TTP) , an RNA binding protein that regulates mRNA degradation, which in turn downregulates TNF and its downstream genes, thus resulting in anti-inflammatory effects
Liu et al., Carcinogenesis 2013
(Leukemia) :
Overexpression of
TTP suppressed HQ-induced
TNF-a upregulation and restored the viability of HQ-treated cells
Ray et al., PloS one 2013
:
Tristetraprolin mediates radiation induced
TNF-a production in lung macrophages
Hochdörfer et al., Cell Signal 2013
:
LPS induced production of
TNF-a and IL-6 in mast cells is dependent on p38 but
independent of
TTP
Inglot et al., Arch Immunol Ther Exp (Warsz) 1993
:
Tolpa Torf Preparation (TTP) induces interferon and
tumor necrosis factor production in human peripheral blood leukocytes
Carballo et al., Science 1998
:
Tristetraprolin (TTP) , the prototype of a class of Cys-Cys-Cys-His ( CCCH ) zinc finger proteins,
inhibited TNF-alpha production from macrophages by destabilizing its messenger RNA