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HDAC2 — MMP2
Text-mined interactions from Literome
Liu et al., Cancer Res 2003
(Lung Neoplasms...) :
In this study, we test the possibility that
HDAC inhibitor may increase RECK expression to
inhibit MMP activation and cancer cell invasion ... To explore whether
HDAC inhibitor induced inhibition of
MMP-2 activation is indeed
mediated via RECK, we used small interference RNA ( siRNA ) to block RECK expression and found that inhibition of RECK by siRNA abolished the inhibitory effect of TSA on MMP-2 activation
Wang et al., J Cereb Blood Flow Metab 2011
(Brain Edema...) :
Our findings suggest that BBB protection by VPA involves
HDAC inhibition
mediated suppression of NF-?B activation,
MMP-9 induction, and tight junction degradation