Gene interactions and pathways from curated databases and text-mining

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CAPN1 — CAPNS1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lancaster et al., Inflammation 2001 (Endotoxemia...) : Calpain-1 inhibitor (CI-1) blocks activation of NF-kappaB by preventing proteolysis of the inhibitory protein IkappaB-alpha by the ubiquitin/proteasome pathway
Wang et al., Oncogene 2003 (Breast Neoplasms) : Treatment of ZR75 cultures with calcium+A23187 recapitulated the formation of the calcium/calpain induced LMW forms of cyclin E. Altered calcium homeostasis and/or inability of the endogenous calpain inhibitor to control the activity of high levels of the calpain small subunit may contribute to increased calpain activity in breast tumors, causing abundant levels of LMW cyclin E
Altznauer et al., J Biol Chem 2004 (Cystic Fibrosis) : Calpain-1 regulates Bax and subsequent Smac dependent caspase-3 activation in neutrophil apoptosis ... Calpain-1 regulates Bax and subsequent Smac dependent caspase-3 activation in neutrophil apoptosis
Corasaniti et al., Br J Pharmacol 2007 : Calpain I activity and the activation ( phosphorylation ) of Akt and glycogen synthase kinase-3beta ( GSK-3beta ) were assayed by Western blotting ... Calpain I activity and the activation ( phosphorylation ) of Akt and glycogen synthase kinase-3beta ( GSK-3beta ) were assayed by Western blotting
Jiang et al., PloS one 2008 : Calpain-1 activation is required for MMP2 expression in fibroblasts and is induced in cardiomyocytes by Ang II
Li et al., Cardiovasc Res 2009 (Hyperglycemia) : Calpain-1 activation induces apoptosis through down-regulation of the Na+/K+ ATPase activity in high glucose stimulated cardiomyocytes and in vivo hyperglycaemic hearts
Gafni et al., J Biol Chem 2009 : Calpain-1 cleaves and activates caspase-7
Shimizu et al., J Orthop Res 1991 : Calpain I requires a low concentration of Ca2+ for activation, and calpain II requires a much higher Ca2+ concentration
Murachi et al., Prog Clin Biol Res 1990 : Calpain I requires low ( or microM ) -Ca2+ for activation and calpain II requires high ( or mM ) -Ca2+ ... Calpain I requires low ( or microM ) -Ca2+ for activation and calpain II requires high ( or mM ) -Ca2+
Prangsaengtong et al., Hum Cell 2012 : Calpain 1 is involved in the degradation of eNOS and Hsp90 and the phosphorylation of eNOS, while calpain 2 regulates eNOS phosphorylation during cord formation by lymphatic endothelial cells on Matrigel ... Calpain 1 is involved in the degradation of eNOS and Hsp90 and the phosphorylation of eNOS , while calpain 2 regulates eNOS phosphorylation during cord formation by lymphatic endothelial cells on Matrigel
Jiang et al., Hypertension 2012 (Calcinosis...) : Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age associated aortic wall calcification and fibrosis
Murachi et al., Adv Exp Med Biol 1989 : Calpain I requires low Ca2+ for activation and calpain II requires high Ca2+ ... Calpain I requires low Ca2+ for activation and calpain II requires high Ca2+
Ando et al., Biochem Biophys Res Commun 1987 : Calpain I activated platelet factor XIII up to 76 % of the maximum level observed with thrombin