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LPA — SELE

Text-mined interactions from Literome

Rizza et al., Lab Invest 1999 : LPA but not phosphatidic acid dose-dependently increased E-selectin and vascular cell adhesion molecule-1 ( VCAM-1 ) cell surface expression ... The selective receptor antagonists N-palmitoyl-serine and N-palmitoyl-tyrosine ( which inhibits PSP24 ) completely inhibited LPA induced VCAM expression ; however these antagonists inhibited E-selectin expression by only 30 %, suggesting a role for at least one additional LPA receptor mediating E-selectin expression ... The effects of both LPA and sphingosine-1-phosphate on the induction of both VCAM-1 and E-selectin expression was abolished by pretreatment with pertussis toxin suggesting that both LPA receptors in HAEC couple to a Gi pathway
Takami et al., Circulation 1998 : We evaluated the effect of Lp(a) on the expression of intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, and E-selectin in human umbilical vein endothelial cells by a cell ELISA ... In contrast to ICAM-1, the expression of VCAM-1 and E-selectin was not significantly affected by Lp(a)