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FGFR1 — MAPK3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lopez et al., J Biol Chem 2000
:
These findings indicate that
FGFR-1L binds FGF-1 and FGF-2 with high affinity and is capable of mitogenic signaling, but may
activate MAPK to occur via non-classical signaling intermediates
Hart et al., Oncogene 2000
(Cell Transformation, Neoplastic) :
Phosphorylation of Shp2, PLC-gamma, and
MAPK was also
stimulated by all three ` TDII-like '
FGFR derivatives
Gaubert et al., J Biol Chem 2001
:
The expression of a dominant negative
FGFR1 did not
reduce ERK-1/2 activation by the HMW FGF-2, suggesting that ERK activation does not require FGFR activity
Koziczak et al., Oncogene 2004
(Breast Neoplasms) :
The repression of
FGFR activity
caused downregulation of
MAPK in MDA-MB-415 and MDA-MB-453 cells
Cotton et al., J Cell Sci 2006
:
FGFR-1 activation also
resulted in the downstream suppression of
mitogen activated protein kinase signaling
Easton et al., J Neurochem 2006
(Neuroblastoma) :
In addition to Shc,
fibroblast growth factor receptor substrate 2 (FRS2) is
required for the BDNF induced activation of
MAPK
Lunn et al., Dev Biol 2007
:
To begin to assess specificity downstream of FGF in the chick embryo we have characterised the patterns of
Fgfr1-4 expression and
Erk1/2 activation , as well as expression of the Erk1/2 specific phosphatase, Mkp3 and of three Ets factor genes ( Erm, Pea3 and Er81 ) from early blastula to the 10 somite stage
Kuslak et al., Differentiation 2007
(MAP Kinase Signaling System) :
Blocking FGFR activation with PD173074 showed that activation of
extracellular signal regulated kinase 1/2 ( ERK1/2 ) in the UGS is
dependent on
FGFR signaling
Dong et al., Blood 2007
(Cell Transformation, Neoplastic...) :
We found that
ZNF198-FGFR1 activated both the AKT and
mitogen activated protein kinase ( MAPK ) prosurvival signaling pathways, resulting in elevated phosphorylation of the AKT target FOXO3a at T32 and BAD at S112, respectively
Soundararajan et al., J Neurosci 2010
(MAP Kinase Signaling System) :
These results indicate that
MAPK/ERK activation downstream of
FGFR1 is necessary for MMCm motor axon guidance and that ES cell derived neurons provide an important tool for dissecting intracellular pathways required for axon guidance
Mavila et al., PloS one 2012
(Liver Neoplasms) :
FGF Receptor ( R ) activation
resulted in the downstream activation of
MAPK , PI3K-AKT, and ß-catenin pathways, as well as cellular proliferation
Kenerson et al., Gastroenterology 2013
(Carcinoma, Hepatocellular...) :
Inhibition of
fibroblast growth factor receptor 1 in Tsc1-null mice
suppressed Akt and
mitogen activated protein kinase activities in tumor cells
Lonic et al., J Biol Chem 2013
(MAP Kinase Signaling System) :
Phosphorylation of serine 779 in
fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon)
regulates Ras/mitogen activated protein kinase signaling and neuronal differentiation