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EPHB2 — PTCH1
Text-mined interactions from Literome
Mitsutake et al., Endocrinology 2006
(Carcinoma, Papillary...) :
Conditional
RET/PTC3 expression
induced comparable ERK phosphorylation in CRAF knockdown and control cells but negligible
ERK phosphorylation in BRAF knockdown cells
Iavarone et al., J Biol Chem 2006
(MAP Kinase Signaling System...) :
By using RET/PTC3 molecules mutated in specific tyrosine autophosphorylation sites, we characterized Tyr ( 981 ), a known binding site for c-Src, as a major determinant of
RET/PTC3 induced
Erk8 activation, although, surprisingly, the underlying mechanism did not strictly depend on the activity of Src
Knostman et al., Thyroid 2007
(Carcinoma, Papillary...) :
Only one line had thyroid targeted, doxycycline regulated RET/PTC1 and luciferase coexpression, in which doxycycline induction of
RET/PTC1 led to
Erk phosphorylation and reduced expression of the sodium/iodide symporter ( NIS )