Gene interactions and pathways from curated databases and text-mining

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EPHB2 — PTCH1

Text-mined interactions from Literome

Mitsutake et al., Endocrinology 2006 (Carcinoma, Papillary...) : Conditional RET/PTC3 expression induced comparable ERK phosphorylation in CRAF knockdown and control cells but negligible ERK phosphorylation in BRAF knockdown cells
Iavarone et al., J Biol Chem 2006 (MAP Kinase Signaling System...) : By using RET/PTC3 molecules mutated in specific tyrosine autophosphorylation sites, we characterized Tyr ( 981 ), a known binding site for c-Src, as a major determinant of RET/PTC3 induced Erk8 activation, although, surprisingly, the underlying mechanism did not strictly depend on the activity of Src
Knostman et al., Thyroid 2007 (Carcinoma, Papillary...) : Only one line had thyroid targeted, doxycycline regulated RET/PTC1 and luciferase coexpression, in which doxycycline induction of RET/PTC1 led to Erk phosphorylation and reduced expression of the sodium/iodide symporter ( NIS )