◀ Back to STAT3
BCL2 — STAT3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Rebbaa et al., Mol Med 2001
(Neuroblastoma) :
Up-regulation of Stat3 phosphorylation and
Bcl-xL expression,
increased nuclear translocation of
phospho-Stat3 , and binding to DNA occurred only in resistant SKN-SH/Dox6 cells
Schweizer et al., J Cell Biol 2002
(Facial Nerve Injuries) :
Stat3 is
essential for upregulation of Reg-2 and
Bcl-xl expression in lesioned motoneurons
Yoshida et al., J Exp Med 2002
(Cell Transformation, Neoplastic...) :
Activation of
STAT3 by the HCV core in NIH-3T3 cells
resulted in rapid proliferation and up-regulation of
Bcl-XL and cyclin-D1
Real et al., Oncogene 2002
(Brain Neoplasms...) :
Resistance to chemotherapy via
Stat3 dependent overexpression of
Bcl-2 in metastatic breast cancer cells ... Furthermore, transfection of 435B with a dominant negative Stat3 markedly reduced the expression of Bcl-2 protein, whereas transient expression of a constitutively active
Stat3 increased
Bcl-2 in parental 435 cells
Moodley et al., Am J Respir Cell Mol Biol 2003
(MAP Kinase Signaling System...) :
Using RNase protection assays, we showed that IL-6 enhanced Fas induced apoptosis and expression of Bax in normal-Fb, but inhibited apoptosis and induced expression of
Bcl-2 in IPF-Fb. Densitometry of Western blots revealed a Bcl-2/Bax ratio 0.15 +/- 0.01 in normal-Fb compared with 12.05 +/- 1.0 in IPF-Fb. Upregulation of Bcl-2 in normal-Fb and Bax in IPF-Fb were both
STAT-3 dependent
Konnikova et al., BMC cancer 2003
(Astrocytoma) :
Moreover,
STAT3 is
required for the expression of the antiapoptotic genes survivin and
Bcl-xL in the A172 glioblastoma cell line
Rust et al., J Pathol 2005
(Lymphoma, Large B-Cell, Diffuse) :
Activated
STAT3 leads to the induction of several genes such as Mcl-1,
Bcl-2 and Bcl-X ( L ), and tissue inhibitor of metalloproteinase ( TIMP ) -1
Bhattacharya et al., Biochem J 2005
:
STAT3 mediated transcription of
Bcl-2 , Mcl-1 and c-IAP2 prevents apoptosis in polyamine depleted cells ... These results suggest that activation of
STAT3 in response to polyamine depletion
increases the transcription and subsequent expression of anti-apoptotic
Bcl-2 and IAP family proteins and thereby promotes survival of cells against TNF-alpha induced apoptosis
Akasaki et al., J Biol Chem 2006
(Glioma) :
Reduction of
pY705-STAT3 in glioma cells
caused down-regulation of FLIP ( FADD-like IL-1beta converting enzyme-inhibitory protein ) and
Bcl-2
Lu et al., J Biol Chem 2006
:
Not only the up-regulation of p50alpha and p55alpha but also the repression of cyclin D1 and
Bcl-2 in SOCS3 ( -/- ) MEFs was
inhibited by dominant negative
STAT3
Kim et al., Mol Endocrinol 2007
(Carcinoma, Papillary...) :
Chromatin immunoprecipitation studies indicate that expression of LKB1 reduces the binding of STAT3 to its target promoters and suppresses
STAT3 mediated expression of Cyclin D1, VEGF, and
Bcl-xL
Lee et al., Int J Cancer 2008
(Carcinoma, Squamous Cell...) :
A signal network
involving coactivated NF-kappaB and
STAT3 and altered p53 modulates
BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
Delgado et al., Dig Dis Sci 2008
(Adenocarcinoma...) :
This drug significantly reduced the up-regulations of cyclin D1, cyclin E, c-Myc, and
Bcl-2 as well as the
activation of
STAT3 in SEG-1 cells
Chen et al., Cancer Biol Ther 2008
(Neoplasms...) :
Activated
STAT3 mediated VEGF induction of EC
Bcl-2 and contributed to VEGF protection of EC from apoptosis
Marrero et al., Brain Res 2009
(Inflammation) :
In this study, we investigated the effects of inhibiting the alpha7 nAChR-JAK2 pro-survival cascade on the nicotine induced production of the survival factor
Bcl-2 and the transcriptional
activation of NF-kappaB, AP-1, STAT1,
STAT3 , and STAT5
Choi et al., Exp Mol Med 2009
:
STAT3 is
involved in phosphatidic acid induced
Bcl-2 expression in HeLa cells ... Furthermore, STAT3 siRNA treatments inhibited PA-induced Bcl-2 expression, suggesting that
STAT3 ( Ser727 ) is
involved in PA-induced
Bcl-2 expression
Chen et al., J Mol Neurosci 2010
(Brain Neoplasms...) :
In addition, down-regulation of
Stat3 can
suppress the expression of MMP-2,
Bcl-xL and survivin but not 67LR
Glienke et al., Tumour Biol 2011
(Pancreatic Neoplasms) :
siRNA targeting STAT3 was used to evaluate the
role of
STAT3 in modulating the expression of Survivin/BIRC5 and
BCL-xL in the pancreatic cancer cell lines PANC-1 and BxPC-3 and induction of apoptosis
Zhao et al., Cytokine 2011
(Brain Injuries) :
Moreover, AG490 attenuated rhEPO 's neuroprotection by down regulating rhEPO induced activation of
JAK2/STAT3 , and
inhibiting Bcl-2 and
Bcl-xl
Sun et al., Journal of translational medicine 2012
:
Down regulation of
STAT-3 with siRNA
resulted in a reduced expression of
Bcl-2 and cyclin D1
Zhang et al., Proc Natl Acad Sci U S A 2012
(Breast Neoplasms...) :
BP-1-102 mediated inhibition of aberrantly active
Stat3 in tumor cells
suppresses the expression of c-Myc, Cyclin D1,
Bcl-xL , Survivin, VEGF, and Krüppel-like factor 8, which is identified as a Stat3 target gene that promotes Stat3 mediated breast tumor cell migration and invasion
Tu et al., Cancer Lett 2012
(Bone Neoplasms...) :
The inhibition of
STAT3 in Saos-2 cells by siRNA or AG490 decreased cell proliferation, migration and invasion,
down-regulated the mRNA expression of Cyclin D,
Bcl-xL and Survivin and enhanced the apoptotic response
Zgheib et al., Eur Cytokine Netw 2012
(Cardiomegaly...) :
Different effects of LIF were seen in protein levels of genes associated with STAT3 in the left ventricle : levels of SOD2 and
Bcl-xL were unchanged, but levels of total
STAT3 and MCP-1 were
increased
Zhang et al., Cell Biol Int 2013
:
Both
Bcl-2 and Mcl-1 in ADAM8 overexpressing A549 cells were profoundly
diminished by
STAT3 knockdown
Khan et al., BioMed research international 2013
(Liver Neoplasms) :
This alantolactone induced apoptosis was found to be associated with GSH depletion,
inhibition of
STAT3 activation, ROS generation, mitochondrial transmembrane potential dissipation, and increased
Bax/Bcl-2 ratio and caspase-3 activation