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DRAM2 — TP53

Text-mined interactions from Literome

Crighton et al., Cell 2006 (Carcinoma...) : We show that p53 induces autophagy in a DRAM dependent manner and, while overexpression of DRAM alone causes minimal cell death, DRAM is essential for p53 mediated apoptosis
Ghavami et al., PloS one 2011 : Simvastatin concomitantly increased p53 dependent expression of p53 up-regulated modulator of apoptosis ( PUMA ), NOXA, and damage regulated autophagy modulator ( DRAM ) ... Notably both mevalonate cascade inhibition induced autophagy and apoptosis were p53 dependent : simvastatin increased nuclear p53 accumulation, and both cyclic pifithrin-a and p53 shRNAi partially inhibited NOXA, PUMA expression and caspase-3/7 cleavage ( apoptosis ) and DRAM expression, Atg5-12 complex formation, LC3 lipidation, and autophagosome formation ( autophagy )
Valbuena et al., PloS one 2011 : Induction of DNA damage by UV, IR, etoposide and doxorubicin stabilizes p53 and induces DRAM expression, followed by VRK1 downregulation and a reduction in p53 Thr18 phosphorylation ... DRAM expression is induced by wild-type p53 , but not by common human p53 mutants, R175H, R248W and R273H
Yoon et al., Mol Biol Rep 2012 : As its name implies, DRAM expression induces autophagy in a p53 dependent manner ; however, the role of DRAM2 in autophagy is not clear
Ghavami et al., Am J Physiol Lung Cell Mol Physiol 2012 : Notably, GGT1 inhibition induced expression of p53 dependent proteins, p53 upregulated modulator of apoptosis ( Noxa ), and damage regulated autophagy modulator ( DRAM ), this was inhibited by the p53 transcriptional activation inhibitor cyclic-pifithrin-a
Laforge et al., PLoS Pathog 2013 (HIV Infections) : Herein, we demonstrate that HIV infection induces damage regulated autophagy modulator ( DRAM ) expression in a p53 dependent manner