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MSK9 — TP53
Text-mined interactions from Literome
Llanos et al., Science signaling 2009
(MAP Kinase Signaling System) :
MSK2 inhibits
p53 activity in the absence of stress ... Mitogen- and stress activated kinase 2 (
MSK2 )
inhibits the transcription factor
p53 , and we investigate here the mechanisms underlying this inhibition
Gesser et al., Inflamm Res 2011
(Psoriasis) :
Dimethylfumarate inhibits MIF induced proliferation of keratinocytes by inhibiting
MSK1 and RSK1 activation and by
inducing nuclear p-c-Jun ( S63 ) and
p-p53 ( S15 ) expression ... Our results indicate that the specific inhibitory effects of DMF on RSK1 and
MSK1 activation together with the
induction of p-c-Jun ( S63 ) and
p-p53 ( S15 ) lead to the inhibition of keratinocyte proliferation, partly explaining the anti-psoriatic effect of DMF