Gene interactions and pathways from curated databases and text-mining

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PECAM1 — TP53

Text-mined interactions from Literome

Park et al., Mol Carcinog 2012 (Colonic Neoplasms...) : HFD feeding increased tumor tissue levels of Ki67, cyclin A, cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced p53 levels and TUNEL positive apoptotic cells ; increased the levels of CD45, CD68, CD31 , VEGF, P-VEGF receptor-2, iNOS, and COX-2 as well as hemoglobin content ; and increased the levels of HIF-1a, P-STAT3-Y705, P-STAT3-S727, P-I?B-a, P-p65, p65, P-c-Jun, P-Akt, P-ERK1/2, P-p38, and P-SAPK/JNK
Charpin et al., Am J Clin Pathol 1995 (Breast Neoplasms...) : Also the CD31 immunoreactivity was independent of the pHER-2/neu, Ki67 antigen, p53 , ER, PR and pS2 immunodetectable expression in tumors, but correlates with that of cathepsin D ( P = .024 ) and P-gp ( P = .028 ), which reflects the multi-drug resistance capacity of tumor cells