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RELA — STAT6
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Abu-Amer et al., J Clin Invest 2001
:
IL-4 abrogates osteoclastogenesis through
STAT6 dependent inhibition of
NF-kappaB ... The results show that excess unlabeled consensus sequence
STAT6 , but not its mutated form,
inhibits NF-kappaB binding
Wei et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
Consistent with this observation, the inhibitory effects of IL-4 on RANKL induced
NF-kappa B and mitogen activated protein kinase activation are
STAT6 dependent
Nelson et al., J Cell Sci 2003
:
NF-kappaB signalling is
inhibited by glucocorticoid receptor and
STAT6 via distinct mechanisms
Zamorano et al., J Immunol 2003
:
To test this hypothesis, we analyzed the
effect of known inhibitors of
NF-kappaB on the activation of
STAT6
Dedeoglu et al., Int Immunol 2004
:
IL-4
induced STAT6 binding to a site in the 5 ' upstream region of the AID gene, while CD40 ligation induced
NFkappaB binding to two sites in that region
Hirayama et al., Arthritis Rheum 2005
(Arthritis, Experimental...) :
We have previously shown that IL-4 inhibits osteoclastogenesis in vitro through inhibition of
NF-kappaB and JNK activation in a
STAT-6 dependent manner
Thieu et al., J Leukoc Biol 2007
:
IL-4 stimulated
NF-kappaB activity is
required for
Stat6 DNA binding