Gene interactions and pathways from curated databases and text-mining

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LOX — TP53

Text-mined interactions from Literome

Torosyan et al., Cancer Res 2006 (Adenocarcinoma...) : On the other hand, wild-type p53 restored 5-LOX expression in DU145 to levels comparable to benign prostate epithelial cells ... Thus, ANXA7 and p53 can distinctly regulate LOX transcription that is potentially relevant to the AA-mediated cell growth control in tumor suppression
Bishayee et al., Acta Biochim Biophys Sin (Shanghai) 2013 (Neoplasms) : Lastly, suppression of 5-LOX activity that reduces the cell proliferation activity also induces intrinsic mitochondrial apoptotic pathway in either p53 dependent or independent manner