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MDM1 — TP53

Text-mined interactions from Literome

Yu et al., Oncogene 2000 : In the current study, MDM2 mediated degradation of p53 was partially inhibited in cells treated with leptomycin B ( LMB ), a specific inhibitor of nuclear export
Inoue et al., FEBS Lett 2001 : Importantly, MDM2 overexpression inhibited the stabilization of p53 and decrease in ubiquitination following MMC, MMS, and UV treatment
Gu et al., Blood 2002 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : In the presence of wild-type ( wt ) p53 , MDM2 increased p65 promoter activity by reversing p53 mediated suppression of p65 ... In the absence of p53 , MDM2 directly increased p65 promoter activity
Jin et al., J Biol Chem 2002 : Consistent with the above results, MDM2 significantly repressed the activation of p53 transcriptional activity by PCAF without apparently affecting the level of p53
Wei et al., J Biol Chem 2003 (Osteosarcoma) : In contrast, MDM2 inhibits p53 by promoting its degradation
Ko et al., Oncogene 2003 (Cell Transformation, Neoplastic...) : In HCCR-2 transfected NCI-H460 cells and RKO cells, stabilization of the p53 tumor suppressor occurred without genetic mutation and correlated with functional impairment, as indicated by the defective induction of p53 induced p21 ( WAF1 ), MDM2 , and bax
Zhao et al., J Biol Chem 2004 : Interestingly, whereas Daxx did not bind to p53 in cells as assessed by immunoprecipitation, MDM2 expression restored p53-Daxx interaction, and this correlated with deacetylation of p53
Lin et al., Oncogene 2005 (Bone Neoplasms...) : Overexpressed myc tagged topors associates with and stabilizes p53, and enhances the p53 dependent transcriptional activities of p21 ( Waf1 ), MDM2 and Bax promoters and elevates endogenous p21 ( Waf1 ) mRNA levels
Wiederschain et al., J Biol Chem 2005 (Translocation, Genetic) : Our data show that MLL-AF9, MLL-AF10, MLL-ENL, and MLL-ELL substantially down-regulate p53 mediated induction of p21, MDM2 , and Bax in response to DNA damage
Wang et al., EMBO J 2005 : Therefore, MDM2 interaction with KAP1 contributes to p53 functional regulation
Toledo et al., Int J Biochem Cell Biol 2007 (Neoplasms) : We now know that MDM2 and MDM4 inhibit p53 in distinct and complementary ways : MDM4 regulates p53 activity, while MDM2 mainly regulates p53 stability
Phang et al., Eur J Cancer 2008 (Leukemia) : Although mutations in p53 are rare in leukaemia, MDM2 , the negative regulator of p53 , is often overexpressed
Markey et al., Frontiers in bioscience (Landmark edition) 2011 (Neoplasms) : Under normal growth conditions, MDM4 contributes to the repression of p53 activity
Vaughan et al., Genes & cancer 2011 : Consistently, analysis of functional domains of MDM2 indicated that although the p53-interaction domain of MDM2 contributes to the up-regulation of the NF?B2 promoter, MDM2 does not require direct interactions with p53 for this function