◀ Back to BCL10
BCL10 — IKBKG
Pathways - manually collected, often from reviews:
-
KEGG T cell receptor signaling pathway:
Complex of BCL10-CARD11-MALT1
→
IKBKG
(protein-protein, activation)
-
KEGG B cell receptor signaling pathway:
Complex of BCL10-CARD11-MALT1
→
IKBKG
(protein-protein, activation)
-
NCI Pathway Database BCR signaling pathway:
IKK complex complex (CHUK-IKBKB-IKBKG)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, collaborate)
-
NCI Pathway Database Canonical NF-kappaB pathway:
BCL10/MALT1/TRAF6 complex (BCL10-MALT1-TRAF6)
→
NEMO (IKBKG)
(modification, activates)
Zhou et al., Nature 2004
Evidence: mutant phenotype
-
Reactome Reaction:
BCL10
→
IKBKG
(indirect_complex)
Shinohara et al., J Exp Med 2005, Sommer et al., Immunity 2005, Shinohara et al., Immunol Rev 2009
-
Reactome Reaction:
BCL10
→
IKBKG
(reaction)
Wang et al., Nature 2001, Zhou et al., Nature 2004, Shinohara et al., J Exp Med 2005, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Shinohara et al., Immunol Rev 2009, Zhang et al., Chin Med Sci J 2010
-
WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection:
Complex of MALT1-CARD11-BCL10
→
Complex of IKBKG-IKBKB-CHUK
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
IKBKG
—
BCL10
Zhou et al., Nature 2004
-
IRef Bind_translation Interaction:
IKBKG
—
BCL10
(affinity chromatography technology)
Zhou et al., Nature 2004
-
IRef Bind_translation Interaction:
IKBKG
—
BCL10
(coimmunoprecipitation)
Zhou et al., Nature 2004
-
IRef Biogrid Interaction:
BCL10
—
IKBKG
(direct interaction, pull down)
Wu et al., Proc Natl Acad Sci U S A 2008*
-
IRef Biogrid Interaction:
BCL10
—
IKBKG
(direct interaction, pull down)
Stilo et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
BCL10
—
IKBKG
(physical association, affinity chromatography technology)
Poyet et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
BCL10
—
IKBKG
(physical association, affinity chromatography technology)
Park et al., Proc Natl Acad Sci U S A 2013*
-
IRef Biogrid Interaction:
BCL10
—
IKBKG
(physical association, affinity chromatography technology)
Wu et al., Proc Natl Acad Sci U S A 2008*
-
IRef Biogrid Interaction:
BCL10
—
IKBKG
(physical association, affinity chromatography technology)
Bhattacharyya et al., J Biol Chem 2010*
-
IRef Dip Interaction:
IKBKG
—
BCL10
(physical association, anti bait coimmunoprecipitation)
Wu et al., Proc Natl Acad Sci U S A 2008*
-
IRef Dip Interaction:
IKBKG
—
BCL10
(physical association, pull down)
Wu et al., Proc Natl Acad Sci U S A 2008*
-
IRef Dip Interaction:
IKBKG
—
BCL10
(physical association, anti tag coimmunoprecipitation)
Wu et al., Proc Natl Acad Sci U S A 2008*
-
IRef Hprd Interaction:
BCL10
—
IKBKG
(in vitro)
Zhou et al., Nature 2004
-
IRef Hprd Interaction:
BCL10
—
IKBKG
(in vivo)
Zhou et al., Nature 2004
-
IRef Innatedb Interaction:
IKBKG
—
BCL10
(unknown, -)
Zhou et al., Nature 2004
-
IRef Intact Interaction:
IKBKG
—
BCL10
(physical association, anti bait coimmunoprecipitation)
Shambharkar et al., EMBO J 2007
-
IRef Ophid Interaction:
IKBKG
—
BCL10
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Zhou et al., Nature 2004
(Lymphoma, B-Cell, Marginal Zone) :
Paracaspase and a ubiquitin conjugating enzyme ( UBC13 ) were both required for
Bcl10 induced
NEMO ubiquitination and subsequent NF-kappaB activation
Patke et al., Curr Opin Immunol 2004
:
BCR signaling leads to
activation of the inhibitor of NF-kappa B kinase
(IKK) complex via Carma1,
Bcl10 and MALT1, whereas BAFF-R engagement promotes processing of NF-kappa B2 protein p100, which is dependent on NF-kappa B-inducing kinase (NIK) and IKK alpha
Sun et al., Mol Cell 2004
(Lymphoma, B-Cell, Marginal Zone) :
Strikingly, only these oligomeric forms of
BCL10 and MALT1 can
activate IKK in vitro
Hinz et al., Science's STKE : signal transduction knowledge environment 2007
:
IKK triggers
Bcl10 degradation by the ubiquitin-proteasome system through phosphorylation of Bcl10 at other sites