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CHUK — TRAF3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
TRAF3
—
CHUK
(interaction, mapped from bind)
-
STRING interaction:
CHUK
—
TRAF3
(interaction, mapped from grid)
Text-mined interactions from Literome
Takeuchi et al., Antioxid Redox Signal 2000
:
Our data show that TRX treatment inhibits NF-kappaB dependent transcription at the level of downstream of TRAFs and upstream of NIK : TRX inhibited TRAF2-,
TRAF5- , and TRAF6 induced NF-kappaB activation but does not
inhibit NIK-,
IKKalpha- , and MEKK induced activation
Kovalenko et al., Nature 2003
:
CYLD has deubiquitinating activity that is directed towards non-K48 linked polyubiquitin chains, and negatively modulates
TRAF mediated activation of
IKK , strengthening the notion that ubiquitination is involved in IKK activation by TRAFs and suggesting that CYLD functions in this process
Sun et al., Mol Cell 2004
(Lymphoma, B-Cell, Marginal Zone) :
RNAi mediated silencing of MALT1, TAK1,
TRAF6 , and TRAF2
suppressed TCR dependent
IKK activation and interleukin-2 production in T cells
Guasparri et al., EMBO Rep 2006
:
TRAF2, but not
TRAF3 ,
mediates the association of vFLIP with the
IkappaB kinase complex
Matta et al., J Biol Chem 2007
:
Furthermore, endogenously expressed TRAF2 and
TRAF3 do not interact with K13 and
play no role in K13 induced NF-kappaB activation or its interaction with the
IKK complex
Blackwell et al., Mol Cell Biol 2013
:
Here, by assessing the kinetics and amplitude of I?B kinase ( IKK ) activation, we report that TNF-a induced immediate and robust activation of IKK requires K63 linked and linearly linked ubiquitination of RIP1 and that in the absence of RIP1 expression,
TRAF2 and cIAP1 cooperatively
induce delayed
IKK activation by recruiting LUBAC to TNFR1
Valente et al., Cell Signal 2013
:
We investigated the role of TRAF3 interacting protein 2
(TRAF3IP2) , a redox-sensitive adapter protein and an upstream regulator of
IKK and JNK in interleukin (IL)-18
induced smooth muscle cell migration, and the mechanism of its inhibition by simvastatin