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ANG — RAF1
Text-mined interactions from Literome
Smith et al., Endocrinology 1999
(Second Messenger Systems) :
Ang II
caused a rapid and transient activation of
Raf-1 that reached a peak at 5-10 min. Ang II was a potent stimulus of Raf-1 activation with an ED50 of 10 pM and a maximal response at 1 nM, although higher Ang II concentrations elicited a submaximal response
Guillemot et al., J Biol Chem 2000
:
Using a pharmacological and a co-transfection approach, we found that p21(ras),
Raf-1 , phosphatidylinositol 3-kinase and also the catalytic activity of SHP-2 and its Src homology 2 domains are
required for cyclin D1 promoter/reporter gene activation by
Ang II through the regulation of MAPK/ERK activity