◀ Back to SMAD3

SMAD1 — SMAD3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: SMAD3 — SMAD1 (coimmunoprecipitation) Barrios-Rodiles et al., Science 2005
• IRef Biogrid Interaction: SMAD1 — SMAD3 (direct interaction, two hybrid) Wu et al., Mol Cell Biol 1997*
• IRef Biogrid Interaction: SMAD1 — SMAD3 (physical association, affinity chromatography technology) Brown et al., J Cell Biochem 2008
• IRef Hprd Interaction: SMAD1 — SMAD3 (in vivo) Barrios-Rodiles et al., Science 2005
• IRef Ophid Interaction: SMAD3 — SMAD1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: SMAD1 — SMAD3 (interaction, mapped from grid reactome kegg_pathways)
• STRING interaction: SMAD3 — SMAD1 (interaction, mapped from grid reactome kegg_pathways)

Text-mined interactions from Literome

Harada et al., J Biol Chem 2003 : HIPK2 efficiently inhibited Smad1/4 induced transcription from the Smad site containing promoter
Sowa et al., J Biol Chem 2004 : Menin and Smad3 were co-immunoprecipitated, and combined menin and Smad3 overexpression antagonized, whereas menin and the dominant negative Smad3DeltaC together enhanced BMP-2 induced transcriptional activity of Smad1/5 and Runx2
Bharathy et al., Cancer Res 2008 (Carcinoma, Squamous Cell...) : In contrast, a second mutant ( TGFBR2 ( R537P ) ) is associated with high intrinsic kinase activity, loss of Smad2/3 activation, and constitutive activation of Smad1/5
Matsubara et al., J Biol Chem 2008 : Furthermore, overexpression of Smad1 and Smad4 up-regulated Osterix expression, and an inhibitory Smad , Smad6, markedly suppressed BMP2 induced Osterix expression in the Runx2-deficient cells
Moro et al., Life Sci 2008 (Carbon Tetrachloride Poisoning...) : Glycyrrhetinic acid did not affect gene expression of TGF-beta receptors or Smad proteins, but inhibited nuclear accumulation of Smad3 in activated hepatic stellate cells
Jin et al., J Cell Physiol 2009 : Further, km23-2 was required for TGFbeta stimulation of Smad3 dependent Smad binding element ( SBE ) 2-Luc transcriptional activity, but not for TGFbeta stimulation of Smad2 dependent activin responsive element ( ARE ) -Lux transcriptional activity
Finnson et al., Osteoarthritis Cartilage 2010 (Osteoarthritis) : Endoglin enhances TGF-ß1 induced Smad1/5 phosphorylation and inhibits TGF-ß1 induced Smad2 phosphorylation, Smad3-driven transcriptional activity and ECM production in human chondrocytes
Brandl et al., J Cell Sci 2010 : IKKa regulates canonical TGFß-SMAD signaling by interacting with SMAD3 and controlling SMAD complex formation on DNA
Ellman et al., Gene 2013 : The synergism results from LfcinB mediated activation of Sp1 and SMAD signaling pathways by ( i ) phosphorylation of SMAD 1/5/8 ; ( ii ) downregulation of SMAD inhibitory factors [ i.e., noggin and SMAD6 ( inhibitory SMAD ) ] ; and ( iii ) upregulation of SMAD4 ( universal co-SMAD )
Kretzschmar et al., Genes Dev 1997 : Smad1 is regulated in this fashion by BMP receptors, and Smad2 and Smad3 by TGF-beta and activin receptors