Dixon et al., J Clin Invest 2001
(Colonic Neoplasms) :
In particular, we found that the RNA-stability factor HuR binds to the COX-2 ARE, and overexpression of HuR , as detected in tumors, results in elevated expression of COX-2, VEGF, and IL-8 Choi et al., Toxicol Appl Pharmacol 2009
:
Moreover, the interference with HuR protein production suppressed ribotoxic DON induced IL-8 secretion and its mRNA stability