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CD4 — FYN
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
Fyn (FYN)
→
TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70)
(modification, activates)
Kwon et al., EMBO J 2005, Han et al., Science 1998, Michel et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
Fyn (FYN)
→
TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247)
(modification, collaborate)
van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
Evidence: assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
Fyn (FYN)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
Evidence: assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(modification, collaborate)
van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
Evidence: assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD4+ T cells:
SHP2 (PTPN11)
→
TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247)
(modification, inhibits)
Kwon et al., EMBO J 2005, da Silva et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
Text-mined interactions from Literome
Mamchak et al., J Immunol 2008
:
Fyn-deficient mice have greatly decreased numbers of NKT cells and have thymocytes and T cells with compromised responses following Ab crosslinking of their TCRs. Herein we have addressed the
role of
Fyn in peptide/MHC class II-induced
CD4 ( + ) T cell responses
Baldari et al., Eur J Immunol 1995
(Second Messenger Systems) :
Here, we report that cross linking of
CD4 on the surface of Jurkat cells using monoclonal antibodies
results in activation of the CD3 associated kinase
p59fyn ... Co-cross linking of
CD4 and CD3
results in synergistic activation of
p59fyn ... The p59fyn kinase is also hyperactive in a Jurkat cell line stably transfected with a constitutively active p56lck mutant, indicating that p56lck mediates
CD4 activation of
p59fyn
Raab et al., Biochem Biophys Res Commun 1996
:
Ligation of the T cell receptor complex and
CD4 leads to activation of the protein tyrosine kinases p56lck and
p59fyn resulting in phosphorylation of TcR zeta chain and the recruitment of ZAP-70