McGill et al., Cell 2002
(Melanoma...) :
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability ... Mitf also regulates BCL2 in osteoclasts, and both Mitf ( mi/mi ) and Bcl2 ( -/- ) mice exhibit severe osteopetrosis
Lekmine et al., Biochem Biophys Res Commun 2007
(Disease Progression...) :
In addition, Mitf induces Bcl-2 expression following transfection of UISO-Mel-6 cells
Zhuang et al., Mod Pathol 2007
(Disease Progression...) :
The results were also consistent with a role for AP-2 and MITF in regulation of Bcl-2 and pStat3 in regulation of Bcl-XL
Hornyak et al., Pigment Cell Melanoma Res 2009
:
Microphthalmia associated transcription factor ( Mitf ) is essential for melanocyte development and function and regulates anti-apoptotic Bcl2 expression