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AVP — EPHB2
Text-mined interactions from Literome
Byron et al., J Biol Chem 2002
:
ERK1/2 kinases did not appear to be involved because 1 ) 100 pm
AVP did not appreciably
increase ERK1/2 phosphorylation and U-0126 ( 2.5 microm ) did not inhibit AVP stimulated Ca ( 2+ ) spiking ; and 2 ) epidermal growth factor ( 10 nm ) robustly stimulated ERK1/2 phosphorylation but did not induce Ca ( 2+ ) spiking
Ghosh et al., J Cell Biochem 2004
:
Role of protein kinase C in
arginine vasopressin stimulated
ERK and p70S6 kinase phosphorylation ... In this paper, we extend these observations and show that different protein kinase C ( PKC ) isoforms play different roles in mediating
AVP stimulated
ERK1/2 and p70S6 kinase phosphorylation and cell proliferation ... In addition, inhibition of conventional and novel PKC isoforms by chronic ( 24 h ) exposure to phorbol 12-myristate 13-acetate ( PMA ) inhibited
AVP induced
activation of
ERK and p70S6 kinase as well as EGF-R phosphorylation ... Our results indicate that PKCdelta plays an important role in
AVP stimulated
ERK and p70S6 kinase activation and cell proliferation
Keegan et al., Breast Cancer Res Treat 2006
(Breast Neoplasms...) :
Exogenous AVP ( 1, 10, and 100 nM ) elevated
phospho-ERK1/2 levels, and increased cell proliferation was observed in the
presence of 10 nM
AVP
Umenishi et al., Biochim Biophys Acta 2006
:
However,
AVP also
activated both
ERK and CREB pathways, and ERK inhibitor attenuated the upregulation of AQP2 expression
Reif et al., American journal of physiology. Renal physiology 2011
(Cysts...) :
Tolvaptan caused a concentration dependent inhibition of AVP induced cAMP production with an apparent IC ( 50 ) of ~10 ( -10 ) M. Correspondingly, tolvaptan inhibited
AVP induced
ERK signaling and cell proliferation
Tahara et al., Clin Exp Pharmacol Physiol 2012
:
Staurosporine also markedly attenuated the high glucose induced downregulation of V ( 1A ) receptors on mesangial cells and blocked the depressed [ Ca ( 2+ ) ] ( i ) response and increased
ERK activity
induced by
AVP
Zhu et al., Mol Pharmacol 2013
:
These studies demonstrated that both Gaq/PKC- and GRK2/ß-arrestin1 dependent V1AR signaling were capable of inducing
ERK1/2 phosphorylation in
response to
AVP stimulation