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CHRD — FGF1
Text-mined interactions from Literome
Londin et al., Dev Biol 2005
:
We observed that
FGF signaling is
required for
chordin expression but that it also acts via other mechanisms to repress BMP transcription during late blastula stages
Maegawa et al., Development 2006
:
By contrast, when
FGF signaling is inhibited, beta-catenin did not
induce goosecoid and
chordin , repress bmp4 expression or induce a dorsal axis ... These experiments show that FGF dependent organizer function operates through both bozozok RNA accumulation and a pathway consisting of beta-catenin -- > Squint -- > FGF -- > Chordin, in which each component is sufficient for expression of the downstream factors of the pathway, and in which Nodal signaling is required for FGF gene expression and
FGF signaling is
required for Squint induction of
chordin
Varga et al., Mech Dev 2007
:
Chordin expression,
mediated by Nodal and
FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo