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BDNF — FRS2

Pathways - manually collected, often from reviews:

• NCI Pathway Database SHP2 signaling: FRS2 family-active (FRS3/FRS2) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
  Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database SHP2 signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, activates)
  Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family-active (FRS3/FRS2) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
  Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, activates)
  Dixon et al., Biochim Biophys Acta 2006, Hadari et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family (FRS3/FRS2) (modification, activates) Meakin et al., J Biol Chem 1999, Ong et al., Mol Cell Biol 2000, Dixon et al., Biochim Biophys Acta 2006, Guiton et al., J Biol Chem 1995, Stephens et al., Neuron 1994, Obermeier et al., J Biol Chem 1993
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: FRS2 family-active (FRS3/FRS2) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
  Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) (modification, activates)
  Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/SHP2 complex (FRS3_FRS2-PTPN11) (modification, activates)
  Kao et al., J Biol Chem 2001
  Evidence: physical interaction

Text-mined interactions from Literome

Easton et al., J Neurochem 2006 (Neuroblastoma) : BDNF induces phosphorylation of FRS2 ... However, BDNF does not induce phosphorylation of FRS2 in cells expressing a deletion mutant of TrkB ( TrkBDeltaPTB ) missing the juxtamembrane NPXY motif ... Now, we have intriguing data that indicates BDNF induces association of the SH2 domain containing protein tyrosine phosphatase, Shp2, with FRS2 ... Moreover, the PTB association motif of TrkB containing tyrosine 484 is required for the BDNF induced association of Shp2 with FRS2 and the phosphorylation of Shp2
Minegishi et al., FEBS Lett 2009 : Stimulation with brain derived neurotrophic factor (BDNF) enhanced FRS2beta phosphorylation and the cup/ring shaped pattern