McDuff et al., PloS one 2011
(Cell Transformation, Neoplastic) :
Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization ... Furthermore, NPM-ALK attenuates p53 activity in an Rb and MDM2 dependent manner but this activity is not sufficient to bypass senescence
Li et al., Biomed Environ Sci 2011
(Lymphoma, Large-Cell, Anaplastic) :
We also reveal a dynamic chain relation that NPM-ALK regulates p53 expression and subsequent apoptosis cascade in ALK+ ALCLs