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NOTCH1 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Laws et al., Eur J Immunol 2004
:
p53 regulates thymic
Notch1 activation ... We hypothesize that
p53 regulates
Notch activity during T cell development ... These data indicate that
p53 negatively
regulates Notch1 activation during T cell development
Beverly et al., Cancer Res 2005
(Cell Transformation, Neoplastic...) :
Therefore, it is the suppression of p53 that provides the Achilles heel for Notch induced tumors, as activation of
p53 in the
presence of
Notch signaling drives tumor regression
Duan et al., Biol Cell 2006
(Tongue Neoplasms) :
Activated
Notch1 also
led to dramatic increase in p21 ( WAF1/CIP1 ) and
p53 expression with decreases in Skp2 ( S-phase kinase associated protein 2 ) and Bcl-2 ( B-cell lymphocytic-leukaemia proto-oncogene 2 ) expression, which may participate in the induction of apoptosis and cell cycle arrest
Kim et al., Cell Death Differ 2007
:
Furthermore,
Notch1-IC expression
inhibits the phosphorylation of ectopically expressed
p53 in HCT116 p53 ( -/- ) cells as well as the phosphorylation of endogenous p53 in UV-treated HCT116 p53 ( +/+ ) cells
Yugawa et al., Mol Cell Biol 2007
:
Regulation of
Notch1 gene expression by
p53 in epithelial cells
Alimirah et al., Neoplasia (New York, N.Y.) 2007
(Neoplasms) :
Moreover,
p53 mediated induction of
Notch1 expression was associated with stimulation of the activity of Notch-responsive reporters ... Notably,
p53 differentially
regulated the expression of
Notch family members : expression of Notch2 and Notch4 was not induced by p53 ... Together, our observations suggest that
p53 mediated upregulation of
Notch1 expression in human cancer cell lines contributes to cell fate determination after genotoxic stress
Purow et al., Carcinogenesis 2008
(Brain Neoplasms...) :
Subsequent experiments showed that
p53 , an activator of the EGFR promoter, is
regulated by
Notch-1 ... Experiments with p53 positive and -null cell lines confirmed that
p53 partially
mediates the effects of
Notch-1 on EGFR expression ... These results show for the first time that Notch-1 upregulates EGFR expression and also demonstrate
Notch-1 regulation of
p53 in gliomas
Mandinova et al., EMBO J 2008
:
Notch1 expression and activity are significantly induced, in a
p53 dependent manner, by UVB exposure of primary keratinocytes as well as intact epidermis of both mouse and human origin
Kolev et al., Nat Cell Biol 2008
(Carcinoma, Squamous Cell...) :
The underlying mechanism for negative control of the
Notch1 gene in human cells, as well as in a mouse model of EGFR dependent skin carcinogenesis,
involves transcriptional suppression of
p53 by the EGFR effector c-Jun
Ban et al., Cancer Res 2008
(Sarcoma, Ewing) :
EWS-FLI1 suppresses
NOTCH activated
p53 in Ewing 's sarcoma
Secchiero et al., Blood 2009
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Taken together, these data indicate that the
p53 dependent up-regulation of
Notch1 in response to Nutlin-3 represents an antiapoptotic feedback mechanism able to restrain the potential therapeutic efficacy of Nutlin-3 in hematologic malignancies
Yugawa et al., Cancer Res 2010
(Uterine Cervical Neoplasms) :
Conversely, overexpression of DeltaNp63alpha decreased basal levels of
Notch1 , increased proliferative potential of normal human keratinocytes, and
inhibited both
p53 dependent and p53 independent induction of Notch1 and differentiation markers upon genotoxic stress and serum exposure, respectively
Lim et al., Hepatology 2011
(Carcinoma, Hepatocellular...) :
We found that
Notch1 expression in HCC tissues and cell lines is differentially
affected by
p53WT and mutant p53 (p53Mut) ... Virally mediated expression or silencing of p53WT or p53Mut confirmed that
p53WT overexpression
causes Notch1 up-regulation in HCC ... CONCLUSION : In the presence of
p53WT ,
Snail/Notch1 activation
increased the invasiveness of HCC cells
Garg et al., Gastroenterology 2011
(Colitis...) :
Inhibition of
Notch1 signaling significantly
reduced protein levels of active Notch1,
p53 , p21WAF1/Cip1, Bax-1, active caspase-3, as well as apoptosis, compared with controls
Desplats et al., J Biol Chem 2012
(Disease Models, Animal...) :
a-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via
p53 mediated repression of
Notch1
Mahamodhossen et al., Med Oncol 2013
:
Some of these markers are
p53 induced miR-205, leptin receptor antagonist peptide, enhancer of zeste homolog 2 and
Notch 1 pathway components, each of them could offer different mechanism for target therapy in TNBC
Bae et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2013
:
The present study aimed to determine whether the mutant
p53 can be a potent transcriptional
activator of the
Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin induced apoptosis ... Overexpression of mutant
p53 increased
Notch1 promoter activity, whereas knockdown of mutant p53 by small interfering RNA suppressed Notch1 expression, leading to the induction of cellular apoptosis