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TP53 — YY1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
YY1
—
TP53
Sui et al., Cell 2004*
-
IRef Bind_translation Interaction:
YY1
—
TP53
(coimmunoprecipitation)
Sui et al., Cell 2004*
-
IRef Bind_translation Interaction:
YY1
—
TP53
(cosedimentation through density gradient)
Sui et al., Cell 2004*
-
IRef Bind_translation Interaction:
YY1
—
TP53
(affinity chromatography technology)
Sui et al., Cell 2004*
-
IRef Biogrid Interaction:
YY1
—
TP53
(direct interaction, pull down)
Sui et al., Cell 2004*
-
IRef Biogrid Interaction:
YY1
—
TP53
(direct interaction, pull down)
Wu et al., Nature structural & molecular biology 2007
-
IRef Biogrid Interaction:
YY1
—
TP53
(direct interaction, pull down)
Wan et al., Am J Pathol 2012*
-
IRef Biogrid Interaction:
YY1
—
TP53
(direct interaction, pull down)
Grönroos et al., Proc Natl Acad Sci U S A 2004*
-
IRef Biogrid Interaction:
YY1
—
TP53
(physical association, affinity chromatography technology)
Grönroos et al., Proc Natl Acad Sci U S A 2004*
-
IRef Biogrid Interaction:
YY1
—
TP53
(physical association, affinity chromatography technology)
Sui et al., Cell 2004*
-
MIPS CORUM YY1-MDM2-p53 complex:
YY1-MDM2-p53 complex complex (MDM2-TP53-YY1)
Sui et al., Cell 2004*
-
IRef Corum Interaction:
Complex of YY1-MDM2-TP53-TP53-YY1-MDM2
(association, cosedimentation through density gradient)
Sui et al., Cell 2004*
-
IRef Ophid Interaction:
YY1
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Lee et al., Biochem Cell Biol 1999
:
NF1 or
YY1 binds to the motif and
regulates the expression of the human
p53 gene in a tissue-specific manner ... In vitro transcription assay also confirmed that the NF1-like protein regulated the p53 transcription in rat spleen, although the human
p53 transcription was
regulated by
YY1 in that organ
Nayak et al., Mol Biol Rep 1999
(Breast Neoplasms) :
Recently, a tissue specific binding of NF1/YY1 to p53 promoter has been reported and further, it has been demonstrated that
NF1/YY1 activates
p53 promoter activity
Sui et al., Cell 2004
:
We find that
YY1 ablation
results in
p53 accumulation due to a reduction of p53 ubiquitination in vivo ... Conversely,
YY1 overexpression
stimulates p53 ubiquitination and degradation ... Importantly, the tumor suppressor p14ARF compromises the Hdm2-YY1 interaction, which is important for
YY1 regulation of
p53
Bain et al., Eur J Cell Biol 2005
(Carcinoma) :
Targeted inhibition of the transcription factor
YY1 in an embryonal carcinoma cell line
results in retarded cell growth, elevated levels of
p53 but no increase in apoptotic cell death
Gordon et al., Oncogene 2006
(Neoplasms) :
Molecular mechanisms that have been investigated include
YY1 mediated downregulation of
p53 activity, interference with poly-ADP-ribose polymerase, alteration in c-myc and nuclear factor-kappa B (NF-kappaB) expression, regulation of death genes and gene products, and differential YY1 binding in the presence of inflammatory mediators
Santiago et al., Circ Res 2007
:
Additionally,
YY1 induces ubiquitination and proteasome dependent degradation of
p53 , decreasing p53 immunoreactivity in the artery wall
Bheda et al., Oncogene 2008
:
We conclude that acute loss of p53 in normal HKc induces EGFR expression by a mechanism that involves
YY1 and Sp1 and does not
require p53 binding to the EGFR promoter
He et al., Int J Gynecol Cancer 2011
(Papillomavirus Infections...) :
In HPV positive HeLa cells, small interfering RNA mediated
YY1 inhibition induced apoptosis and
increased the expression of
p53 ... In addition,
YY1 inhibition
induces p53 activation and apoptosis in HPV infected HeLa cells
Furlong et al., Mol Cell Biol 1996
:
YY1 and NF1 both
activate the human
p53 promoter by alternatively binding to a composite element, and YY1 and E1A cooperate to amplify p53 promoter activity