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Li et al., Zhonghua Yi Xue Za Zhi 1998 (Hypoproteinemia...) : rhGH significantly up-regulated albumin mRNA expression in vitro ( 143 +/- 6 vs 100.4 +/- 2.2, P < 0.01 ) and in vivo ( 152 +/- 8 Vs 100 +/- 3, P < 0.01 ), and obviously alleviated the inhibition of albumin mRNA expression induced by LPS ( P < 0.05 )
Wang et al., Zhonghua Wai Ke Za Zhi 2004 : To investigate the potential molecular mechanism underlying down-regulation of albumin expression induced by lipopolysaccharide (LPS) in rat hepatocytes ... The results indicate that LPS can induce the reduction of albumin synthesis by down-regulation of albumin mRNA expression at transcription level, and the process may be related to the signal transducation of extracellular signal regulated kinase and p38 kinase
Wang et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004 : CHX could block the pathway of LPS induced down-regulation of expression of albumin gene at least at the transcription level ... The results suggest that LPS can indirectly inhibit the transcription of albumin gene through cytokines such as IL-6 and TNF-alpha
Wang et al., J Surg Res 2004 : The present studies were performed to identify whether the reduction of albumin expression induced by LPS was mediated by activating nuclear factor kappa B(NF-kappaB) in cultured rat hepatocytes ... This reduction in albumin expression induced by LPS can be completely inhibited by SN50 in different concentrations, and the maximal increase in albumin was observed at a SN50 dosage of 30 microg/ml ... The results suggest that LPS inhibits albumin expression by activating NF-kappaB signaling
Wang et al., Hepatobiliary Pancreat Dis Int 2005 : LPS can inhibit albumin synthesis in rat hepatocytes by prevention of albumin transcription
Wang et al., Chin Med J (Engl) 2005 (MAP Kinase Signaling System) : The present study was designed to identify if the reduction of albumin expression is directly induced by LPS and modulated by activated extracellular signal regulated protein kinase ( ERK ) and p38 mitogen activated protein kinase ( MAPK ) in rat hepatocytes ... The ERK inhibitor PD98059 caused a significant increase in LPS induced albumin production at the three concentrations ( 119.7, 111.4 and 80.0 ng/ml vs 44.4 ng/ml, P=0.0013, 0.0025 and 0.009, respectively ), whereas SB203580 obviously blocked albumin reduction in LPS treated cells at the concentrations of 10 and 50 micromol/L ( 87.5 and 93.6 ng/ml vs 44.4 ng/ml, P=0.0076 and 0.0049, respectively ) ... LPS can induce the reduction of albumin expression by new synthesized proteins indirectly, and the process may be related to the signal proteins of ERK and p38 kinase
Borrelli et al., Clinical and vaccine immunology : CVI 2008 : The binding of anti-peptide polyclonal antibodies to LPS could be inhibited by LPS, PS, MDWNMHAA, and MDWNMHAA-bovine serum albumin , as assessed by inhibition enzyme linked immunosorbent assay
Uchiba et al., Am J Physiol 1996 : The intravenous administration of AT III prevented the pulmonary accumulation of leukocytes ( as evaluated by myeloperoxidase activity ) and the increase in pulmonary vascular permeability to 125I-bovine serum albumin induced by LPS
Jungi et al., Infect Immun 1997 : Macrophages were activated by LPS in the presence of serum or in the presence of albumin demonstrated to be free of LBP