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JAK2 — OSM

Text-mined interactions from Literome

Halfter et al., Brain Res Mol Brain Res 2000 (Glioblastoma...) : Activation of the Jak-Stat- and MAPK-pathways by oncostatin M is not sufficient to cause growth inhibition of human glioma cells
Li et al., J Immunol 2001 : We demonstrate that OSM rapidly stimulated phosphorylation of Janus kinase (JAK) 1, JAK2 , JAK3, and STAT1 as well as extracellular signal regulated kinase ( ERK ) 1/2, p38, and c-Jun N-terminal kinase 1/2 mitogen activated protein kinases in primary bovine and human chondrocytes
Magrangeas et al., Eur Cytokine Netw 2001 (Melanoma) : The biological effects of OSM involve the activation of Janus kinases ( Jak ) and signal transducer and activator of transcription ( STAT ) factors
Song et al., J Cell Biochem 2007 : OSM treatment induced activation of JAK2, JAK3 , and ERK in hADSCs, and pre-treatment of hADSCs with the JAK2 inhibitor, AG490, significantly restored the OSM induced inhibition of adipogenic differentiation
Baker et al., Glia 2010 : OSM regulates gene expression primarily by activating the JAK/STAT , NF-kappaB, and/or MAPK pathways, in a cell-type specific manner
Cao et al., J Lipid Res 2011 : Janus kinase activation by cytokine oncostatin M decreases PCSK9 expression in liver cells
Migita et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid) : CP690,550 pretreatment completely abrogated the OSM induced production of IL-6, as well as OSM induced JAK/STAT , and activation of mitogen activated kinases ( MAPKs ) in FLS
Chauhan et al., J Exp Med 1995 : Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells ... In the present study using U266B1 human multiple myeloma cells, we show that OSM induces tyrosine phosphorylation and activation of JAK2 , but not JAK1 or Tyk2, kinases
Faris et al., AIDS 1996 (AIDS-Related Opportunistic Infections...) : Treatment with OSM induced activation of receptor associated JAK and phosphorylation of Stat1 and Stat3
Korzus et al., J Biol Chem 1997 : The mitogen activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element mediated activation of matrix metalloproteinase 1 gene expression
Auguste et al., J Biol Chem 1997 : Both type I and type II OSM receptors activated Jak1, Jak2 , and Tyk2 receptor associated tyrosine kinases