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CXCL12 — HIF1A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Tabatabai et al., Brain 2006
(Brain Neoplasms...) :
Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta dependent
HIF-1alpha mediated
induction of
CXCL12
Nemenoff et al., Circ Res 2008
(Hyperplasia...) :
SDF-1alpha production by other cell types is
regulated by the transcription factor hypoxia-inducible factor
(HIF)-1alpha ... We found SMC nuclear HIF-1alpha expression in PTEN depleted mice and increased nuclear HIF-1alpha in PTEN-deficient SMCs. Small interfering RNA mediated downregulation of
HIF-1alpha reversed SDF-1alpha induction by PTEN depletion and inhibition of phosphatidylinositol 3-kinase signaling
blocked HIF-1alpha and
SDF-1alpha upregulation induced by PTEN depletion