Harris et al., J Cell Sci 2003
:
Rad4 is shown to act upstream of the effector kinases Chk1 and Cds1, as both Chk1 phosphorylation and Cds1 kinase activity require functional Rad4 Sleeth et al., J Mol Biol 2007
:
In addition we show that inhibition of Chk1 with UCN-01 decreases dissociation of RPA from the chromatin and inhibits association of RAD51 and RAD52 with DNA
Parsels et al., Mol Cancer Ther 2009
(Pancreatic Neoplasms) :
Our data suggest the inhibition of this Chk1 mediated Rad51 response to gemcitabine induced replication stress is an important factor in determining gemcitabine chemosensitization by Chk1 inhibition in pancreatic cancer cells
Pal et al., Cancer Genomics Proteomics 2012
(Adenocarcinoma...) :
Suppression of RAD51 in FLO-1 cells down-regulated the expression of CHK2 and CHK1, and reduced the proliferative potential