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EGFR — STAT5B

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT5B → EGFR (increases, EGFR Activity) Kloth et al., J Biol Chem 2003*
  Evidence: We demonstrate that 1) activation of STAT5b by EGF requires overexpression of the EGFR
• OpenBEL Selventa BEL large corpus: STAT5B → EGFR (directlyIncreases, STAT5B Activity) Kloth et al., J Biol Chem 2002*
  Evidence: PhosphoElm data from PMID 15212693
• KEGG ErbB signaling pathway: Complex of EGFR → STAT5A/STAT5B (protein-protein, activation)
• KEGG ErbB signaling pathway: EGFR → STAT5A/STAT5B (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of EGFR-GRB2-STAT5B-CRK
• IRef Bind_translation Interaction: EGFR — STAT5B (coimmunoprecipitation) Schulze et al., Molecular systems biology 2005
• IRef Bind_translation Interaction: EGFR — STAT5B (affinity chromatography technology) Schulze et al., Molecular systems biology 2005
• IRef Biogrid Interaction: EGFR — STAT5B (physical association, affinity chromatography technology) Runge et al., Biochem Biophys Res Commun 1999*
• IRef Hprd Interaction: Complex of 73 proteins (in vivo) Schulze et al., Molecular systems biology 2005
• IRef Hprd Interaction: EGFR — STAT5B (in vitro) Runge et al., Biochem Biophys Res Commun 1999*, Kloth et al., J Biol Chem 2002*
• IRef Hprd Interaction: EGFR — STAT5B (in vivo) Runge et al., Biochem Biophys Res Commun 1999*, Kloth et al., J Biol Chem 2002*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Schulze et al., Molecular systems biology 2005
• IRef Intact Interaction: EGFR — STAT5B (physical association, pull down) Schulze et al., Molecular systems biology 2005
• IRef Ophid Interaction: EGFR — STAT5B (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: EGFR — STAT5B (aggregation, confirmational text mining) Jones et al., Nature 2006

Text-mined interactions from Literome

Kloth et al., J Biol Chem 2003 : We demonstrate that 1 ) activation of STAT5b by EGF requires overexpression of the EGFR , 2 ) co-overexpression of c-Src alone does not result in EGF induced activation of STAT5b but enhances that seen in EGFR overexpressing cells, and 3 ) EGF induced tyrosine phosphorylation of STAT5b requires Tyr ( 845 ) of the EGFR
Peng et al., Nucleic Acids Res 2010 : Taken together, CPEB3 has a novel function in the nucleus as to suppress Stat5b dependent EGFR gene transcription
Hu et al., Proc Natl Acad Sci U S A 2011 (Glioblastoma) : The EGFR-selective tyrosine kinase inhibitors, erlotinib and gefitinib, blocked not only EGFRvIII signaling to ERK but also uPAR dependent STAT5b activation