◀ Back to WNT3
DVL3 — WNT3
Text-mined interactions from Literome
Strovel et al., J Biol Chem 2000
:
PP2C exists in a complex with
Dvl , beta-catenin, and Axin, a negative
regulator of
Wnt signaling
Habas et al., Cell 2001
:
Wnt/Fz activation of Rho
requires the cytoplasmic protein
Dishevelled ( Dvl ) and a novel Formin homology protein Daam1 ... Daam1 binds to both Dvl and Rho, and mediates
Wnt induced
Dvl-Rho complex formation
Shiomi et al., Curr Biol 2003
(Eye Abnormalities) :
In the canonical pathway,
Wnt receptors
activate Dishevelled ( Dvl ) , which then blocks the degradation of a key signal transducer, beta-catenin, leading to the nuclear accumulation of beta-catenin and induction of Wnt target genes through TCF/LEF family transcription factors
Habas et al., Genes Dev 2003
:
Dishevelled ( Dvl ), a cytoplasmic protein downstream of Fz, forms a Wnt induced complex with Rac independent of the
Wnt induced
Dvl-Rho complex
González-Sancho et al., Mol Cell Biol 2004
:
Unlike the effects of Wnt1, phosphorylation of Dvl in response to Wnt5a is not concomitant with beta-catenin stabilization, indicating that
Dvl phosphorylation is not
sufficient to activate canonical
Wnt/beta-catenin signaling ... We conclude that
Wnt induced phosphorylation of
Dvl is independent of LRP5/6 receptors and that canonical Wnts can elicit both LRP dependent ( to beta-catenin ) and LRP independent ( to Dvl ) signals
Esufali et al., Cancer Res 2007
(Colorectal Neoplasms) :
Our results suggest that Rac1b overexpression may facilitate tumor progression by enhancing
Dvl-3 mediated
Wnt pathway signaling and induction of Wnt target genes specifically involved in decreasing the adhesive properties of colorectal cancer cells
Bryja et al., Proc Natl Acad Sci U S A 2007
:
Inhibition of
Wnt signaling by CK1 inhibitors
reduced the binding of beta-arrestin to
Dvl
Gan et al., J Cell Biol 2008
:
Disrupting the interaction of Dvl with either c-Jun or beta-catenin suppresses canonical
Wnt signaling stimulated transcription, and the reduction of
Dvl diminished beta-catenin-TCF-4 association on Wnt target gene promoters in vivo
Etheridge et al., PLoS Genet 2008
(Heart Defects, Congenital...) :
Interestingly, global canonical Wnt signaling appeared largely unaffected in the double Dvl mutants, suggesting that low
Dvl levels are
sufficient for functional canonical
Wnt signals
Qiang et al., Br J Haematol 2010
(Multiple Myeloma) :
Furthermore,
Wnt induced increases in beta-catenin and
Dvl-3 were attenuated by Wnt antagonists Dkk1 and sFRP1
Gao et al., Cell Signal 2010
:
In addition,
Dvl plays important roles in
Wnt-GSK3beta-microtubule signaling, Wnt-calcium signaling, Wnt-RYK signaling, Wnt-atypical PKC signaling, etc
Gao et al., Nat Cell Biol 2010
(Colonic Neoplasms) :
Here we show that autophagy negatively
regulates Wnt signalling by promoting
Dishevelled ( Dvl ) degradation
Perez et al., J Cell Biol 2011
(Neointima) :
Interfering with the
Dvl dependent
Wnt-PCP activation in a murine stented aortic graft injury model promotes extensive neointima formation, as shown by optical coherence tomography and histopathology
Lee et al., Dev Cell 2012
(Wnt Signaling Pathway) :
Biochemical examination found that Daam2 association with
Dvl3 is
required for
Wnt activity and dorsal patterning
Wei et al., Mol Cell Biol 2012
(Wnt Signaling Pathway) :
ITCH ubiquitinates the phosphorylated form of
Dvl and promotes its degradation via the proteasome pathway, thereby
inhibiting canonical
Wnt signaling
Barry et al., Nature 2013
(Colorectal Neoplasms...) :
DVL signals in the nucleus of intestinal stem cells, and its forced expression
leads to enhanced
Wnt signalling in crypts
Kwan et al., PloS one 2013
(Uterine Cervical Neoplasms) :
Enforced expression of DVL3 elevated ß-catenin and augmented cervical cancer cell growth, verifying that
DVL3 mediated
Wnt/ß-catenin activation is involved in cervical cancer oncogenesis
Ding et al., J Biol Chem 2013
(Wnt Signaling Pathway) :
Consistent with the
role of
Dvl in both
Wnt/ß-catenin and Wnt/planar cell polarity signaling, NEDD4L regulates the cellular ß-catenin level and Rac1, RhoA, and JNK activities
Goto et al., PloS one 2013
:
In Xenopus embryos, depletion of IQGAP1 reduced
Wnt induced nuclear accumulation of
DVL , and expression of Wnt target genes during early embryogenesis
Brigelius-Flohé et al., Methods Enzymol 2013
:
NOX1 derived H2O2 oxidizes Nrx leading to the liberation of
Dvl and the
activation of
Wnt signaling