Funkelstein et al., Neuropeptides 2010
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This review describes recent findings indicating the prominent role of cathepsin L in secretory vesicles for production of neuropeptides from their protein precursors ... Cathepsin L is involved in producing opioid neuropeptides consisting of enkephalin, ß-endorphin, and dynorphin, as well as in generating the POMC derived peptide hormones ACTH and a-MSH
Funkelstein et al., Methods Mol Biol 2011
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This review describes research strategies utilizing chemical biology combined with protease gene knockout and expression to demonstrate the key role of cathepsin L for production of neuropeptides in secretory vesicles