Sun et al., J Biol Chem 2002
(Arteriosclerosis...) :
Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein ( a ) Genest et al., Am J Cardiol 1991
(Coronary Disease) :
Stepwise discriminant analysis revealed that Lp(a) was a risk factor for the presence of CAD in men, independent of smoking, hypertension, diabetes, LDL and HDL cholesterol, or apolipoprotein A-I and B levels
Ye et al., J Biol Chem 1988
:
Based on these observations, it was concluded that Lp(a) interacts with LDL2 and other apoB containing lipoproteins which are enriched in triglyceride ; this interaction is due to the presence of apolipoprotein ( a ) and involves lysine residues of apoB interacting with the plasminogen-like domains ( kringle 4 ) of apolipoprotein ( a )