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LPA — ROCK1

Text-mined interactions from Literome

Matsumoto et al., Jpn J Cancer Res 2001 (Bone Neoplasms...) : Lysophosphatidic acid (LPA) activates Rho and ROCK and promotes the organization of stress fibers and focal adhesions
Bian et al., Oncogene 2006 (Ovarian Neoplasms) : Moreover, LPA activated RhoA and Rho kinase ( ROCK ) in a G12/13 dependent manner and their activities were required for LPA induced FAK autophosphorylation
Valenick et al., Matrix Biol 2006 : The soluble factor lysophosphatidic acid (LPA) acts through Rho GTPase and its effector Rho kinase ( ROCK ) to enhance alpha5beta1 integrin mediated cell spreading on the Arg-Gly-Asp ( RGD ) cell binding domain of FN
Iftinca et al., Nat Neurosci 2007 (Retinoblastoma) : Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, whereas Ca(v)3.2 currents showed depolarizing shifts in these parameters ... ROCK activation by LPA reduced native T-type currents in Y79 retinoblastoma and in lateral habenular neurons, and upregulated native Ca(v)3.2 current in dorsal root ganglion neurons
Kitzing et al., Genes Dev 2007 (Neoplasm Invasiveness) : Our results reveal that Dia1 is necessary for LPA stimulated Rho/ROCK signaling and bleb associated cancer cell invasion
Dottori et al., Stem Cells 2008 : LPA acts through the activation of the Rho/ROCK and the phosphatidylinositol 3-kinase/Akt pathways to inhibit neuronal differentiation
Hurst et al., BMC neuroscience 2008 : In contrast, LPA and S1P stimulate transient cell rounding and aggregation that is independent of EGFR and ERK, but dependent on the Rho effector p160 ROCK
Shimada et al., FEBS Lett 2010 : Lysophosphatidic acid (LPA) , an inflammatory mediator that is elevated in multiple inflammatory diseases, is a potent activator of Rho kinase ( ROCK ) signaling and of chemokine production in endothelial cells
Cheng et al., Int Endod J 2011 : After treatment of LPA and Y-27632, a specific ROCK inhibitor , changes in focal contacts ( FCs ) were examined by immunofluorescent staining ... LPA activated Rho and then subsequently activated ROCK , suggesting that LPA influences the FCs of DPCs by modulating tyrosine phosphorylation of FAK and paxillin via the Rho/ROCK pathway
Kim et al., J Cell Physiol 2011 (Breast Neoplasms) : LPA activates ROCK and also increases GTP bound RhoA activity, concomitant with the enhanced membrane recruitment of RhoA