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IGFBP3 — TNF
Text-mined interactions from Literome
Anwar et al., Circulation 2002
(Arteriosclerosis) :
TNF-alpha , a cytokine that is upregulated in atherosclerotic plaques, reduces IGF-1 and
increases IGFBP-3 in VSMCs, likely leading to a reduction in bioactive IGF-1
Liu et al., Endocr J 1999
:
Both IL-1beta and
TNF-alpha inhibited
IGFBP-3 ( 42/38 KDa species ) production in a concentration dependent manner judged by Western ligand blot
Ye et al., J Neurosci Res 2003
:
Histological analysis and immunocytochemical staining confirmed that
TNF-alpha specifically
increases IGFBP-3 and IGFBP-4 immunoreactivity, as well as that of the IGF1R, in radial glial and Purkinje cells
Leibowitz et al., J Cell Physiol 2009
:
Here we show that
TNF-alpha requires the SAPK pathway p38, but not JNK, to induce
IGFBP-3 expression
Mohanraj et al., PloS one 2013
(Atherosclerosis...) :
IGFBP-3 further
inhibits TNF-a , CRP and high glucose induced NF-?B activity in human aortic endothelial cells ( HAECs ) and subsequently suppresses monocyte adhesion to HAEC through the IGFBP-3 receptor
Besset et al., Endocrinology 1996
:
TNF alpha stimulated predominantly
IGFBP-3 ( about 4-fold ) both in terms of mRNA ( a 2.6-kilobase transcript, measured by Northern blotting analysis ), and protein ( a doublet of 40-44 kDa, assessed by ligand blotting analysis )
Qu et al., Metabolism 1998
(Protein Deficiency) :
Since insulin-like growth factor-I (IGF-I) is an important hormone regulator of intestinal proliferation, this study examined the
effects of dietary protein content and
tumor necrosis factor (TNF) on mRNA levels of IGF-I, IGF-I receptor,
IGF binding protein-3 (IGFBP-3) , and IGFBP-4 and on the histology of the colon, jejunum, and ileum in protein malnourished rats
Rozen et al., Int J Oncol 1998
(Breast Neoplasms) :
The increased
IGFBP-3 accumulation
induced by
TNF-alpha is correlated with increased IGFBP-3 mRNA abundance ... Finally, we demonstrate that an IGFBP-3 antisense oligodeoxynucleotide antagonizes TNF-alpha induced inhibition of cell proliferation and
TNF-alpha induced
IGFBP-3 accumulation